Review
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Stem Cells. Jun 26, 2018; 10(6): 57-65
Published online Jun 26, 2018. doi: 10.4252/wjsc.v10.i6.57
Murine models based on acute myeloid leukemia-initiating stem cells xenografting
Cristina Mambet, Mihaela Chivu-Economescu, Lilia Matei, Laura Georgiana Necula, Denisa Laura Dragu, Coralia Bleotu, Carmen Cristina Diaconu
Cristina Mambet, Mihaela Chivu-Economescu, Lilia Matei, Laura Georgiana Necula, Denisa Laura Dragu, Coralia Bleotu, Carmen Cristina Diaconu, Cellular and Molecular Pathology Department, Stefan S. Nicolau Institute of Virology, Bucharest 030304, Romania
Laura Georgiana Necula, Nicolae Cajal Institute, Titu Maiorescu University, Bucharest 040441, Romania
Author contributions: All authors equally contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.
Supported by The project Competitiveness Operational Programme (COP) A1.1.4., No. P_37_798, Contract 149/26.10.2016 (MySMIS2014+: 106774).
Conflict-of-interest statement: No potential conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Mihaela Chivu-Economescu, PhD, Research Assistant Professor, Research Scientist, Senior Researcher, Cellular and Molecular Pathology Department, Stefan S. Nicolau Institute of Virology, 285 Mihai Bravu Ave, Bucharest 030304, Romania. mihaela.chivu@gmail.com
Telephone: +40-21-3242590 Fax: +40-21-3242590
Received: April 28, 2018
Peer-review started: April 28, 2018
First decision: May 11, 2018
Revised: May 24, 2018
Accepted: June 8, 2018
Article in press: June 8, 2018
Published online: June 26, 2018
Core Tip

Core tip: The review is aiming to introduce the field of acute myeloid leukemia (AML) pathogenesis, the concept of leukemic stem cells, and also to present the current attempts to develop best AML animal models as means to investigate the factors responsible for leukemic transformation. Due to difficulties in engraftment of less aggressive AML samples, it is currently being attempted to develop humanized mice by introducing supporting human stromal cells as a source of proper cytokines, in a challenge to mimic an appropriate bone marrow niche able to support leukemic stem cells engraftment.