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World J Stem Cells. Sep 26, 2014; 6(4): 491-496
Published online Sep 26, 2014. doi: 10.4252/wjsc.v6.i4.491
New advances in the mesenchymal stem cells therapy against skin flaps necrosis
Fu-Gui Zhang, Xiu-Fa Tang
Fu-Gui Zhang, Department of Oral and Maxillofacial Surgery, the Affiliated Hospital of Stomatology, Chongqing Medical University, Chongqing 400016, China
Xiu-Fa Tang, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Zhang FG searched data on internet and write the paper; Tang XF revised the paper.
Correspondence to: Xiu-Fa Tang, MD, Professor, State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, NO. 17, 3 Segment, Renmin South Road, Chengdu 610041, Sichuan Province, China. tangxf1963120@163.com
Telephone: +86-28-85501445 Fax: +86-28-85501445
Received: July 16, 2014
Revised: August 6, 2014
Accepted: August 30, 2014
Published online: September 26, 2014
Processing time: 70 Days and 12.9 Hours
Abstract

Mesenchymal stem cells (MSCs), multipotential cells that reside within the bone marrow, can be induced to differentiate into various cells, such as osteoblasts, adipocytes, chondrocytes, vascular endothelial progenitor cells, and other cell types. MSCs are being widely studied as potential cell therapy agents due to their angiogenic properties, which have been well established by in vitro and in vivo researches. Within this context, MSCs therapy appears to hold substantial promise, particularly in the treatment of conditions involving skin grafts, pedicle flaps, as well as free flaps described in literatures. The purpose of this review is to report the new advances and mechanisms underlying MSCs therapy against skin flaps necrosis.

Keywords: Mesenchymal stem cells; Skin flaps; Endothelial progenitor cells

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