Queiroz A, Albuquerque-Souza E, Gasparoni LM, França BN, Pelissari C, Trierveiler M, Holzhausen M. Therapeutic potential of periodontal ligament stem cells. World J Stem Cells 2021; 13(6): 605-618 [PMID: 34249230 DOI: 10.4252/wjsc.v13.i6.605]
Corresponding Author of This Article
Marinella Holzhausen, DDS, MSc, PhD, Academic Research, Professor, Department of Stomatology, Division of Periodontics, School of Dentistry, University of São Paulo, The Butanta district of Sao Paulo, São Paulo 05508-000, Brazil. marinella@usp.br
Research Domain of This Article
Dentistry, Oral Surgery & Medicine
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Stem Cells. Jun 26, 2021; 13(6): 605-618 Published online Jun 26, 2021. doi: 10.4252/wjsc.v13.i6.605
Therapeutic potential of periodontal ligament stem cells
Aline Queiroz, Emmanuel Albuquerque-Souza, Leticia Miquelitto Gasparoni, Bruno Nunes de França, Cibele Pelissari, Marília Trierveiler, Marinella Holzhausen
Aline Queiroz, Cibele Pelissari, Marília Trierveiler, Laboratory of Stem Cell Biology in Dentistry-LABITRON, Department of Oral and Maxillofacial Pathology, School of Dentistry, University of São Paulo, São Paulo 05508-000, Brazil
Emmanuel Albuquerque-Souza, Leticia Miquelitto Gasparoni, Bruno Nunes de França, Marinella Holzhausen, Department of Stomatology, Division of Periodontics, School of Dentistry, University of São Paulo, São Paulo 05508-000, Brazil
Author contributions: Queiroz A, Albuquerque-Souza E, Gasparoni LM, França BN, and Pelissari C contributed equally to the study; Albuquerque-Souza E performed the illustration; Trierveiler M and Holzhausen M designed the study; all authors have read and approved the final manuscript.
Conflict-of-interest statement: There is no conflict of interest associated with any author and/or coauthor that contributed to this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Marinella Holzhausen, DDS, MSc, PhD, Academic Research, Professor, Department of Stomatology, Division of Periodontics, School of Dentistry, University of São Paulo, The Butanta district of Sao Paulo, São Paulo 05508-000, Brazil. marinella@usp.br
Received: January 15, 2021 Peer-review started: January 15, 2021 First decision: February 14, 2021 Revised: February 24, 2021 Accepted: April 22, 2021 Article in press: April 22, 2021 Published online: June 26, 2021
Abstract
Inflammatory periodontal disease known as periodontitis is one of the most common conditions that affect human teeth and often leads to tooth loss. Due to the complexity of the periodontium, which is composed of several tissues, its regeneration and subsequent return to a homeostatic state is challenging with the therapies currently available. Cellular therapy is increasingly becoming an alternative in regenerative medicine/dentistry, especially therapies using mesenchymal stem cells, as they can be isolated from a myriad of tissues. Periodontal ligament stem cells (PDLSCs) are probably the most adequate to be used as a cell source with the aim of regenerating the periodontium. Biological insights have also highlighted PDLSCs as promising immunomodulator agents. In this review, we explore the state of knowledge regarding the properties of PDLSCs, as well as their therapeutic potential, describing current and future clinical applications based on tissue engineering techniques.
Core Tip: Periodontal ligament stem cells (PDLSCs) have been studied for their potential to regenerate not only the periodontal complex but also other dental and non-dental tissues. We herein discuss the general features of PDLSCs, and their potential for immunomodulatory, and regenerative therapy.
