Inhibition of hepatitis B virus by a novel L-nucleoside, β-L-D4A and related analogues

Table 1 Effect-dosage relationship of inhibition of cell growth by β-L-D4A

Dosage (μM)	n	A value (-x±s)	Inhibition rate (%)
50	3	0.84 ± 0.22	22.3
100	3	0.75 ± 0.16	36.0
150	3	0.73 ± 0.12	37.2
200	3	0.67 ± 0.21	50.4
250	3	0.53 ± 0.15	73.5
300	3	0.43 ± 0.25	89.2
0	3	2.01 ± 0.23	0

Table 2 Effect-dosage relationship of inhibition of HBsAg and HBeAg by β-L-D4A

Dosage(μM)	n	HBsAg		HBeAg
		P/N value	Inhibition	P/N value	Inhibition
0.08	3	2.96 ± 0.18	13.7	4.98 ± 0.23	5.5
0.4	3	2.84 ± 0.22	22.3	4.97 ± 0.15	5.7
2	3	2.75 ± 0.16a	36.0	4.88 ± 0.25	9.4
10	3	2.73 ± 0.12a	37.2	4.02 ± 0.33b	37.5
Blank	3	3.09 ± 0.21	0	5.27 ± 0.27	0

^aP < 0.05;

^bP < 0.01 vs blank control.