Meta analysis of propranolol effects on gastrointestinal hemorrhage in cirrhotic patients

Table 1 Point estimates and 95%CIs of the risk difference of gastrointestinal hemorrhage

	Prapranolol group		Control group		Risk difference and its 95%CI (%)
	Total	Bled	Total	Bled
Primary prevention
Pascal (1984)	34	1	35	9	-23 [-38, -7]
Mills (1987)	38	19	43	33	-27 [-47, -6]
Pascal (1987)	118	20	112	30	-10 [-20, 1]
Italian (1988)	85	16	89	27	-12 [-24, 1]
Strauss (1988)	20	4	16	4	-5 [-33, 23]
Colman (1990)	23	8	25	2	27 [5, 49]
Andreani (1990)	43	2	41	13	-27 [-43,-11]
Conn (1991)	51	4	51	14	-20 [-34, -5]
Prova (1991)	68	23	72	19	7 [-8, 23]
Subtotal	480	97	484	151	-11 [-21, -1]
Overall effect			Z = -2.15	P = 0.03
Secondary prevention
Burroughs (1983)	26	14	22	13	-5 [-33, 23]
Lebrec (1984)	38	6	36	23	-48 [-68,-29]
Cerbelaud (1986)	42	17	42	33	-38 [-57,-19]
Villeneuve (1986)	42	32	37	30	-5 [-23, 13]
Queuniet (1987)	51	29	48	31	-8 [-27, 11]
Marbet (1988)	10	2	10	9	-70 [-101,-39]
Colombo (1989)	32	8	30	14	-22 [-45, 2]
Sheen (1989)	18	8	18	15	-39 [-68,-10]
Garden (1990)	38	20	43	36	-31 [-50,-12]
Colman (1990)	26	9	26	13	-15 [-42, 11]
Perez-Ayuso (1991)	26	16	28	24	-24 [-47, -1]
Calès (1999)	102	3	104	4	-1 [-6, 4]
Subtotal	451	164	444	245	-25 [-39,-10]
Overall effect			Z = -3.34	P = 0.0008
All trials
Total	931	261	928	396	-18 [-25, -10]
Overall effect			Z = -4.38	P = 0.00001

Table 2 Point estimates and 95%CIs of the risk difference of death

	Prapranolol group		Control group		Risk difference and its 95%CI (%)
	Total	Death	Total	Death
Primary prevention
Pascal (1984)	34	1	35	13	-34 [-51, -17]
Mills (1987)	38	15	43	19	-5 [-26, 17]
Pascal (1987)	118	25	112	40	-15 [-26, -3]
Italian (1988)	85	30	89	22	11 [-3, 24]
Strauss (1988)	20	7	16	7	-9 [-41, 23]
Colman (1990)	23	6	25	7	-2 [-27, 23]
Andreani (1990)	43	13	41	18	-14 [-34, 7]
Conn (1991)	51	8	51	11	-6 [-21, 9]
Prova (1991)	68	7	72	14	-9 [-21, 3]
Subtotal	480	112	484	151	-9 [-18, -1]
Overall effect			Z = -2.11	P = 0.03
Secondary prevention
Burroughs (1983)	26	4	22	5	-7 [-30, 15]
Lebrec (1984)	38	3	36	8	-14 [-30, 2]
Cerbelaud (1986)	42	5	42	12	-17 [-33, 0]
Villeneuve (1986)	42	19	37	14	7 [-14, 29]
Queuniet (1987)	51	12	48	13	-4 [-21, 14]
Marbet (1988)	10	1	10	3	-20 [-54, 14]
Colombo (1989)	32	4	30	7	-11 [-30, 8]
Sheen (1989)	18	0	18	2	-11 [-28, 6]
Garden (1990)	38	14	43	19	-7 [-29, 14]
Colman (1990)	26	1	26	1	0 [-10, 10]
Perez-Ayuso (1991)	26	4	28	7	-10 [-31, 12]
Calès (1999)	102	9	104	10	-1 [-9, 7]
Subtotal	451	76	444	101	-5 [-9, -1]
Overall effect			Z = -2.26	P = 0.02
All trials
Total	931	188	928	252	-7 [-12, -3]
Overall effect			Z = -3.44	P = 0.0006