Effect of pinaverium bromide on stress-induced colonic smooth muscle contractility disorder in rats

Table 1 Contractile response to ACh and KCl in colonic circu-lar muscle (mN/mm², ^-x±s)

	ACh (10-5 mol/L)	KCl (60 mmol/L)
Control	71.56 ± 19.36 (n = 8)	73.85 ± 13.08 (n = 9)
Stress	109.66 ± 34.42a (n = 8)	119.54 ± 19.06a (n = 8)

^aP < 0.05, vs control.

Table 2 Effect of pinaverium bromide on the increment of [Ca²⁺]_i (△[Ca²⁺]_i) in response to ACh and KCl (nmmol/L, ^-x±s)

Concentration ofpinaverium (mol/L)	ACh (10-5 mol/L)(n = 7)	KCl (60 mmol/L)(n = 6)
0	94.78 ± 15.99	64.61 ± 8.06
10-7	83.57 ± 13.54	55.73 ± 17.39
10-6	34.73 ± 13.98a	41.71 ± 1.61a
10-5	27.09 ± 5.64a	40.34 ± 10.96a

Figures in this table are the increment of [Ca²⁺]i in response to ACh and KCl. △[Ca²⁺]i = [Ca²⁺]i_{After (ACh,KCl) stimulated}-[Ca²⁺]i_{Before (ACh,KCl) stimulated}.

^aP < 0.05, vs pinaverium 0 mmol/L.