Different alterations of cytochrome P450 3A4 isoform and its gene expression in livers of patients with chronic liver diseases

Table 1 Clinicopathological characteristics of patients studied and their Pugh class

Groups	Median Age (yrs)	Gender F/M	Smoking (n)	Ethanol (n)	Pugh Class A,B,C
C (n = 6)	42 (21-56)	2/4	2	1	A (6)
H (n = 6)	38 (28-61)	1/5	1	1	A (4), B (2)
O (n = 6)	44 (27-65)	0/6	1	2	B (6)

C: Controls; H: Hepatic cirrhosis; O: Obstructive jaundice.

Table 2 Microsomal protein, total P450 content and CYP3A4 content and its activity among three groups (^-x ± s)

	C	H	O
Microsome protein (g/L)	10.32 ± 3.98	9.57 ± 3.72	9.42 ± 3.26
P450 content (nmol/mg protein)	0.99 ± 0.16	0.94 ± 0.151	0.89 ± 0.18
CYP3A4 activity (nmol/min/mg protien)	3.01 ± 0.74	1.78 ± 0.653a	2.89 ± 0.65

^aP < 0.01 versus controls C: Controls; H: Hepatic cirrhosis; O: Obstructive jaundice.