Plasma matrix metalloproteinase-1 and tissue inhibitor of metalloproteinases-1 as biomarkers of ulcerative colitis activity

Table 1 Laboratory and clinical indices of ulcerative colitis activity in the patients

	Normal range	Mean	± SEM	Minimum	Maximum	Median
CRP (mg/dl)	0-5	17.7	4.6	6	62	6
SR (mm/h)	0-12	22.7	4.7	2	68	17
WBC ( × 103/μl)	4-10	6.8	0.5	3.5	11.5	6.2
HGB (mg/dl)	12-16	13.3	0.3	10.5	14.9	13.4
CAI	0	10.6	0.75	7	15	9
DAI	0	6.4	0.7	3	10	5
Endoscopic score	0	11.6	0.8	8	16	10

CAI: clinical activity index, DAI: disease activity index.

Table 2 Correlation between plasma TIMP-1 or MMP-1 concentrations and values of selected laboratory indices, demonstrated through “r” values. Statistically significant correlation: ^aP < 0.05; ^bP < 0.01

	TIMP-1 (r)	MMP-1 (r)
CRP (mg/dl)	0.60a	0.05
SR (mm/h)	0.17	-0.07
WBC (x103/ml)	0.24	-0.10
HGB (mg/dl)	-0.19	-0.10
CAI (clinical activity index)	0.55a	-0.18
DAI (disease activity index)	0.66b	-0.27
Score	0.66b	-0.11