Clinical Research
Copyright ©The Author(s) 2003. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 15, 2003; 9(12): 2843-2845
Published online Dec 15, 2003. doi: 10.3748/wjg.v9.i12.2843
Plasma matrix metalloproteinase-1 and tissue inhibitor of metalloproteinases-1 as biomarkers of ulcerative colitis activity
Alicja Wiercinska-Drapalo, Jerzy Jaroszewicz, Robert Flisiak, Danuta Prokopowicz
Alicja Wiercinska-Drapalo, Jerzy Jaroszewicz, Robert Flisiak, Danuta Prokopowicz, Department of Infectious Diseases, Intestinal Diseases Unit, Medical University of Bialystok, Poland
Author contributions: All authors contributed equally to the work.
Correspondence to: Alicja Wiercinska-Drapalo MD., Department of Infectious Diseases, Medical University of Bialystok, 15-540 Bialystok, Zurawia str., 14, Poland.
Telephone: +48-85-7416921
Received: August 5, 2003
Revised: September 14, 2003
Accepted: October 12, 2003
Published online: December 15, 2003

AIM: Overexpression of mucosal metalloproteinases (MMP) have been demonstrated recently in inflammatory bowel disease. Their activity can be counterbalanced by the tissue inhibitor of metalloproteinases (TIMP). The aim of this study was to evaluate the effect of ulcerative colitis (UC) on MMP-1 and TIMP-1 plasma concentrations, as two possible biomarkers of the disease activity.

METHODS: MMP-1 and TIMP-1 plasma concentrations were measured with an enzyme immunoassay in 16 patients with endoscopically confirmed active UC.

RESULTS: Plasma concentrations of both MMP-1 (13.7 ± 0.2 ng/ml) and TIMP-1 (799 ± 140 ng/ml) were significantly elevated in UC patients in comparison to healthy controls (11.9 ± 0.9 ng/ml and 220 ± 7 ng/ml respectively). There was no correlation between TIMP-1 and MMP-1 concentrations (r = -0.02). TIMP-1 levels revealed significant positive correlations with scored endoscopic degree of mucosal injury, disease activity index and clinical activity index values as well as C-reactive protein concentration. There was no correlation between MMP-1 and laboratory, clinical or endoscopic indices of the disease activity.

CONCLUSION: These results confirm the role of both MMP-1 and TIMP-1 in the pathogenesis of ulcerative colitis. However only TIMP-1 can be useful as a biomarker of the disease activity, demonstrating association with clinical and endoscopic pictures.

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