Expression of Bcl-2 and Bax in extrahepatic biliary tract carcinoma and dysplasia

Table 1 Expression of Bcl-2 and Bax in biliary tract carcinoma and dysplasia lesions

Lesions	Bcl-2 expression			Bax expression
	No. positive/tested	%	P	No. positive/tested	%	P
Bile duct	9/21	42.9	0.363	7/21	81.0	0.290
Ampulla of Vater	1/6	16.7		3/6	50.0
Invasive carcinoma	10/27	37.0	0.110	20/27	74.1	0.038a
Dysplasia	1/10	10.0		3/10	30.0
Normal	0/5	0		2/5	40.0

a: Further compared, it was shown that the difference of Bax expression between dysplasia and normal epithelium was not significant (P = 1.00), but Bax expression of carcinoma differed from that in dysplasia and normal tissues significantly (P = 0.012).

Table 2 Comparison of Bcl-2/Bax protein expression with histological features or clinical stages in biliary tract carcinoma

Histological features	Bcl-2 expression			Bax expression
	No. positive/tested	%	P	No. positive/tested	%	P
Differentiation grade
Well	7/17	41.18		13/17	76.48
Moderately	2/7	28.57		5/7	71.43
Poorly	1/3	33.33	0.846	2/3	66.67	1.000
Perineural invasion
No	4/9	44.44		7/9	77.78
Yes	6/18	33.33	0.236	13/18	72.22	0.209
Vascular invasion
No	8/19	42.11		15/19	78.95
Yes	2/8	25.00	0.666	5/8	62.50	0.633
Lymph node metastasis
No	7/14	50.00		12/14	85.71
Yes	3/13	23.08	0.683	8/13	61.54	1.00 0
Stages
I + II	5/13	38.46		10/13	76.92
III + IV	5/14	35.70	1.000	10/14	71.431	1.000