Association between HLA class II gene and susceptibility or resistance to chronic hepatitis B

Table 1 Allele frequency of HLA-DRB1 in patients with chronic and acute hepatitis B and normal heathy individuals

HLA-DRB1 allele	Normal control (n = 106)		Chronic hepatitis B (n = 52)		Acute hepatitis B (n = 30)
	PN	AF	PN	AF	PN	AF
0101/0103	1	0.47	1	0.96	1	1.67
0301*	12	5.66	18	17.31	6	10.00
0401/0411	24	11.32	13	12.50	7	11.67
0701/0702	11	5.19	8	7.69	4	6.67
0801/0804	9	4.25	6	5.77	3	5.00
0901	32	15.09	16	15.39	8	13.33
1001	2	0.94	2	1.92	1	1.67
1101/1104**	13	6.13	1	0.96	8	13.33
1201/1202	34	16.04	15	14.42	8	13.33
1301/1302	4	1.89	1	0.96	1	1.67
1303/1304	1	0.47	1	0.96	1	1.67
1401, 1404	14	6.60	6	5.77	4	6.67
1402, 1403	0	0.00	0	0.00	0	0.00
1501/1502	34	16.04	11	10.58	5	8.33
1601/1602	13	6.13	2	1.92	1	1.67
Blank	8	3.77	3	2.89	2	3.33

PN: Positive number, AF: Allele frequency. *χ² = 12.3068, Pc = 0.0074, RR = 4.15. **χ² = 11.9206, Pc = 0.0145, RR = 18.55.

Table 2 Allele frequency of HLA-DQA1 in patients with chronic and acute hepatitis B and normal heathy individuals

HLA-DQA1 allele	Normal control (n = 106)		Chronic hepatitis B (n = 52)		Acute hepatitis B (n = 30)
	PN	AF	PN	AF	PN	AF
0101	17	8.02	9	8.65	4	6.67
0102	45	21.23	22	21.15	12	20.00
0103	9	4.25	5	4.81	2	3.33
0104	3	1.42	1	0.96	1	1.67
0201	7	3.30	3	2.88	1	1.67
0301*	57	26.89	15	14.42	18	30.00
0302	1	0.47	0	0.00	0	0.00
0401	2	0.49	1	0.96	1	1.67
0501**	29	13.68	27	25.96	10	16.67
0601	23	10.85	12	11.54	6	10.00
Blank	19	8.96	9	8.65	5	8.33

PN: Positive number, AF: Allele frequency. *χ² = 7.6781, Pc = 0.0388, RR = 3.70. **χ² = 9.2002, Pc = 0.0157, RR = 2.87.

Table 3 Allele frequency of HLA-DQB1 in patients with chronic and acute hepatitis B and normal heathy individuals

HLA-DQB1 allele	Normal control (n = 106)		Chronic hepatitis B (n = 52)		Acute hepatitis B (n = 30)
	PN	AF	PN	AF	PN	AF
0201	23	10.85	10	9.62	6	10.00
0301*	40	18.87	37	35.58	16	26.67
0302	14	6.61	6	5.77	3	5.00
0303	35	16.51	15	14.42	10	16.67
0401	11	5.19	5	4.81	3	5.00
0402	2	0.94	1	0.96	1	1.67
0501	9	4.25	3	2.88	2	3.33
0502	20	9.43	7	6.73	3	5.00
0503	6	2.83	2	1.92	1	1.67
0601	20	9.43	7	6.73	7	11.67
0602	12	5.66	4	3.85	3	5.00
0603	5	2.36	2	1.92	1	1.67
0604	7	3.30	2	1.92	2	3.33
Blank	8	3.77	3	2.89	2	3.33

PN: Positive number, AF: Allele frequency. χ² = 15.5938, Pc = 0.0075, RR = 4.07.