Subcellular daunorubicin distribution and its relation to multidrug resistance phenotype in drug-resistant cell line SMMC-7721/R

Table 1 Effect of AS-ODN on drug sensitivity of cells (¯x ± s)

Cells	IC50 (mg/L)		RI
	DNR	ADM	DNR	ADM
SMMC-7721/S	0.003 ± 0.0006	0.004 ± 0.0008	1.0
SMMC-7721/R	0.264 ± 0.0094	0.463 ± 0.0254	88.0	116.0
AS-ODN/mdrr1	0.094 ± 0.0065	0.079 ± 0.0014	31.4	19.8
AS-ODN/mrp	0.072 ± 0.0002	0.097 ± 0.0009	24.0	24.3
SMMC-7721/R+	0.012 ± 0.0011	0.009 ± 0.0007	4.00	2.3
AS-ODN/mdr1 + mrp
SMMC-7721/R+	0.245 ± 0.0110	0.451 ± 0.0187	81.7	112.8
AS-ODN/nonsense

Values (IC₅₀) represent the mean ± standard deviation of at least three experiments and value (RI) represent the mean of three experiments. All values were calculated as described in MATERIALS AND METHODS. The concentration of each AS-ODN is 0.5 μmol/L and the treatment time is 72 h.