Basic Research
Copyright ©The Author(s) 2002.
World J Gastroenterol. Jun 15, 2002; 8(3): 528-530
Published online Jun 15, 2002. doi: 10.3748/wjg.v8.i3.528
Table 1 Effects of LPS on portal hemodynamics
Dose of LPS (mg·kg-1)PVF (mL·min-1)PPVP (kPa)PPVR (kPa·min·L-1)P
0.0014.0 ± 0.441.04 ± 0.02051
0.1018.0 ± 0.440.0001.05 ± 0.0220.743420.001
0.2522.2 ± 0.660.0001.25 ± 0.0260.000440.003
0.5026.2 ± 0.800.0001.50 ± 0.0150.000480.086
1.0034.8 ± 0.800.0001.80 ± 0.0230.000450.003
2.0039.6 ± 0.740.0001.95 ± 0.0350.000440.001
4.0038.8 ± 0.330.0002.05 ± 0.0220.000470.008
Table 2 Effects of LPS on portal hemodynamics of sham-operated and PHT rats
GroupPVF (mL·min-1)PVP (kPa)PVR (kPa·min·L-1)
Portal vein ligation32.8 ± 1.62.24 ± 0.07361
Control22.6 ± 1.71.86 ± 0.04471
Intrahepatic portal occlusion28.0 ± 2.11.95 ± 0.05461
Control22.0 ± 2.11.74 ± 0.03767
Sham-operated34.8 ± 0.71.80 ± 0.04644
Control14.0 ± 0.41.04 ± 0.03952
Table 3 Alteration of portal hemodynamics of the noncirrhotic and sham-operated rats after injection of LPS
GroupPVF (mL·min-1)Increment (%)PVP (kPa)Increment (%)PVR (kPa·min·ml-1)Increment (%)
PVL10.2 ± 0.845.130.38 ± 0.04720.43-10-14.08
IPO6.4 ± 1.1427.270.21 ± 0.02612.07-10-8.96
Sham-operated20.8 ± 0.84148.570.76 ± 0.03873.08-8-15.38