Effect of Nimesulide on proliferation and apoptosis of human hepatoma SMMC-7721 cells

Table 1 Inhibition effect of Nimesulide on proliferation and growth in hepatic carcinoma cell line SMMC-7721

Nimesulide Concentrations (μmol/L)	OD Value
	the 2nd day	the 3rd day	the 4th day	the 5th day
0	1.039 ± 0.066	1.516 ± 0.117	2.142 ± 0.072	2.467 ± 0.080
200	0.841 ± 0.027a	1.109 ± 0.231a	1.416 ± 0.080a	1.341 ± 0.021a
300	0.796 ± 0.019a	1.002 ± 0.274a	1.101 ± 0.028a	1.243 ± 0.168a
400	0.581 ± 0.164a	0.825 ± 0.016a	0.943 ± 0.032a	1.024 ± 0.026a

^aP < 0.05 vs control group

Table 2 Apoptosis rate of SMMC-7721 cells induced by Nimesulide

Nimesulide concentration (μmol/L)	Apoptosis rate (%)
0	2.24 ± 0.26
200	7.42 ± 0.43b
300	9.84 ± 1.54b
400	21.20 ± 1.62b

^bP < 0.01 vs control group

Table 3 Aapoptosis index of SMMC-7721 cells induced by Nimesulide

Nimesulide concentration (μmol/L)	Apoptosis index (%)
0	2.016 ± 0.23
200	7.64 ± 0.34a
300	10.14 ± 1.42a
400	21.23 ± 1.78a

^aP < 0.05 vs control group