Influence of BOL on hyaluronic acid, laminin and hyperplasia in hepatofibrotic rats

Table 1 Serum HA and LN in BOL treated SD rats (mean ± SD, μg•L¯¹)

Groups	n	HA	LN
Normal	10	197.77 ± 26.02	42.78 ± 10.05
Model	8	806.07 ± 98.49b	133.94 ± 14.45b
Colchicine	9	402.53 ± 50.78a	118.28 ± 16.13b
Low-dose BOL	8	376.15 ± 35.48a	71.99 ± 8.15bdc
High-dose BOL	8	340.14 ± 30.18a	71.68 ± 11.62bdc

^bP < 0.01 vs normal group;

^aP < 0.05 vs model group,

^dP < 0.01 vs model group;

^cP < 0.05 vs colchicine.

Table 2 Extent of liver hyperplasia in each treated group

Groups	n	Degree of liver fibrosis					Average of Ridit
		-	+	++	+++	++++
Model	8	0	0	1	4	3	0.7247
Colchicine	9	0	1	2	4	2	0.5894
Low-dose BOL	8	0	2	1	4	1	0.5176
High-dose BOL	8	0	5	2	1	0	0.2364

χ² = 13.24, χ² (4) = 9.49.

Table 3 Liver cell degeneration in each treated group

Groups	n	Extent of hyperplasia					Average of Ridit
		-	+	++	+++	++++
Model	8	0	0	2	3	3	0.7408
Colchicine	9	0	1	4	3	1	0.5584
Low-dose BOL	8	0	1	2	4	1	0.5599
High-dose BOL	8	0	4	3	1	0	0.2576

χ² = 11.99, χ² (4) = 9.49.