Original Research
Copyright ©The Author(s) 2001.
World J Gastroenterol. Aug 15, 2001; 7(4): 522-526
Published online Aug 15, 2001. doi: 10.3748/wjg.v7.i4.522
Table 1 Relationship between MSI status and frameshift mutation
MSI statusNo. of casesFrameshift mutations
MSH6TGF β RIIBAX
MSI-H8263
MSI-L9000
MSS51000
Table 2 The relationship between the mean TRF length and clinico-pathological pararmeters
ParametersNo. of casesMean TRF length (x-± s)
Gender
Male233.99 ± 0.63
Female124.32 ± 1.00
Age (yrs)
30-3954.54 ± 0.54
40-4974.07 ± 0.60
50-59114.39 ± 0.96
60-69103.69 ± 0.66a
70-7923.40 ± 0.07a
Size
< 5 cm123.80 ± 1.20
> 5 cm234.06 ± 0.86
Differentiation
Well and moderate73.91 ± 0.49
Poor194.24 ± 0.64
Mucinous94.02 ± 1.10
Clinical stage
I and II214.26 ± 0.82
III and IV143.84 ± 0.68
Table 3 Relationship between alterations of TRF length and MSI status or frameshift mutation
No. of casesAlterations in TRF length
Shortened (n = 20)Normal (n = 12)Elongated (n = 3)
MSI status
MSI-H8440
MSI-L9441
MSS18972
Frameshift mutation
MSH335110
TGF β RII35321
BAX35210
Table 4 Relationship between alterations of TRF length and loss of heterozygosity of APC, MCC and DCC genes
LOHAlterations in TRF ength (LOH/Informative)
Shortened (n = 20)Normal (n = 12)Elongated (n = 3)
APC5/131/70/2
MCC6/111/60/2
DCC14/18a3/111/3