Multiple genetic alterations and behavior of cellular biology in gastric cancer and other gastric mucosal lesions: H. pylori infection, histological types and staging

doi:10.3748/wjg.v6.i6.848

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 6, Issue 6

This Article

Citation of this article

Corresponding Author of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (2197)

All Articles published online

The chart showing PDF series, HTML series, Tables (1-5) series.

Item

Count

PDF

219

HTML

1861

Tables (1-5)

117

Sum=2197

Dec 15, 2000 (publication date) through Apr 25, 2024

Times Cited of This Article

Times Cited (37)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Original Articles

World J Gastroenterol. Dec 15, 2000; 6(6): 848-854
Published online Dec 15, 2000. doi: 10.3748/wjg.v6.i6.848

Table 1 Expressions of p53, p16, Bcl-2, and COX-2 proteins in gastric mucosal lesions (n, %)

Lesion	n	p53	p16	Bcl-2	COX-2
GC	60	28 (46.7)^a	23 (38.3)	41 (68.3)^b^a	45 (75.0)^a
Dys	49	10 (20.4)	20 (40.8)	36 (73.5)^b^a	18 (36.7)
IM	78	1 (1.3)	43 (55.1)	33 (42.3)	21 (26.9)
CAG	56	0 (0)	39 (69.6)^a	9 (16.1)	5 (8.9)
CSG	84	0 (0)	67 (79.8)^b	7 (8.3)	0 (0)

p53:

^aP < 0.05 GC-Dys; p16:

^bP < 0.01 CSG-Dys or GC, ^aP < 0.05 CAG-Dys or GC; Bcl-2: ^bP < 0.01 Dys (GC)-CSG or CAG; ^aP < 0.05 Dys (GC)-IM; COX-2: ^aP < 0.05 GC-Dys (IM).

Table 2 Expression rates of p53, p16, Bcl-2, and COX-2 proteins in gastric mucosal lesions with H. pylori infection (n, %)

Protein	CSG (84)		CAG (56)		IM (78)		Dys (49)		GC (60)
Protein	Hp+ (49)	Hp-(35)	Hp+ (31)	Hp-(25)	Hp+ (32)	Hp-(46)	Hp+ (21)	Hp-(28)	Hp+ (33)	Hp-(27)
p53	0	0	0	0	1	0	6 (28.6)	4 (14.3)	17 (515)	11 (40.7)
p16	36 (73.5)	31 (88.6)	17 (54.8)	22 (88.0)^a	11 (34.4)	32 (69.6)^a	5 (23.8)	15 (53.6)^a	11 (33.3)	12 (44.4)
Bcl-2	4 (8.2)	3 (8.6)	6 (19.4)	3 (12.0)	22 (68.8)^a	11 (23.9)	19 (90.5)^a	17 (60.7)	25 (75.6)	16 (59.3)
COX-2	0	0	3 (9.7)	2 (8.0)	16 (50.0)^a	5 (10.8)	13 (61.8)^a	5 (17.8)	26 (78.7)	19 (70.4)

^aP < 0.05 p16: (CAG, IM or Dys) Hp+-Hp-; Bcl-2 or COX-2: (IM or Dys) Hp+-Hp-.

Table 3 The expression intensity of p53, p16, Bcl-2, and COX-2 proteins in gastric mucosal lesions with H. pylori infection (n)

Lesion	Hp	p53				p16				Bcl-2				COX-2
Lesion	Hp	-	+	++	+++	-	+	++	+++	-	+	++	+++	-	+	++	+++
CSG	+					13	17	13	6	45	3	1
	-					4	13	15	3	32	2	1
CAG	+					14b	12	5		25	2	4		28	3
	-					3	5	9	8	22	2	1		23	2
IM	+		1			21b	7	4		10a	4	10	8	16a	5	11
	-					14	4	15	13	35	6	5		41	4	1
Dys	+	15	4	2		16a	2	3		2a	2	11	6	8a	3	10
	-	24	2	2		13	2	8	5	11	9	5	3	23	3	2
GC	+	16	6	8	3	22	4	5	2	8	6	11	8	7	2	17	7
	-	16	4	6	1	15	5	6	1	11	5	9	2	8	4	12	3

^bP < 0.01 p16 (CAG or IM) Hp+-Hp-; ^aP < 0.05 p16 (Dys) Hp+-Hp-; Bcl-2 or COX-2 (IM or Dys) Hp+-Hp-.

Table 4 Comparisons of each parameter of CIA between H. pylori positive and H. pylori negative

parameters	Hp+ (33)	Hp-(33)
Ellipser (μm)	79 ± 23	58 ± 15^b
Ellipseb (μm)	53 ± 14	40 ± 12^a
Ratio₁ (%)	22 ± 5	13 ± 4^b
Ratio₂ (%)	79 ± 17	53 ± 20^b
Area₁ (μm²)	748 ± 572	301 ± 202^a
Area₂ (μm²)	3050 ± 1661	1681 ± 1990^a
Fshape	0.67 ± 0.09	0.71 ± 1.10

^aP < 0.05, Ellipseb, Area₁ or Area₂: Hp+-Hp-;

^bP < 0.01, Ellipser, Ratio₁ or Ratio₂: Hp+-Hp-.

Table 5 Expressions of p53, p16, Bcl-2, and COX-2 proteins in GC related to tumor staging and histological types (n, %)

Lesion	n	p53	p16	Bcl-2	COX-2
Type
Intestinal	24	14 (58.3)	9 (37.5)	18 (75.0)^a	16 (66.7)
Diffuse	6	3 (30.0)	2 (33.3)	1 (16.7)	4 (66.7)
Stage of GC
Early	5	2 (40.0)	2 (40.0)	4 (80.0)	1 (20.0)
Advanced	25	15 (60.0)	9 (36.0)	15 (60.0)	19 (76.0)^a
Grade of differentiation
High or middle	14	6 (42.9)	6 (42.9)	12 (85.7)	8 (57.1)
Low or not	10	8 (80.0)	3 (30.0)	7 (70.0)	8 (80.0)
Lymph node metastasis
No	4	2 (50.0)	2 (50.0)	3 (75.0)	1 (16.7)
Yes	26	15 (57.7)	9 (34.6)	16 (61.5)	19 (79.2)^a

^aP < 0.05 Bcl-2: Intestinal-Diffuse; COX-2: Advanced-Early, Lymph node metastasis Yes-No.

Citation: Gao HJ, Yu LZ, Bai JF, Peng YS, Sun G, Zhao HL, Miu K, Lü XZ, Zhang XY, Zhao ZQ. Multiple genetic alterations and behavior of cellular biology in gastric cancer and other gastric mucosal lesions: H. pylori infection, histological types and staging. World J Gastroenterol 2000; 6(6): 848-854
URL: https://www.wjgnet.com/1007-9327/full/v6/i6/848.htm
DOI: https://dx.doi.org/10.3748/wjg.v6.i6.848