Copyright ©The Author(s) 1998.
World J Gastroenterol. Jun 15, 1998; 4(3): 185-191
Published online Jun 15, 1998. doi: 10.3748/wjg.v4.i3.185
Table 1 Some inherited diseases that affect the liver and the genes that were indentified in the 1990s by molecular biological and genetic methods.
Wilson diseaseCu-transporting ATPase
Hereditary hemochromatosisHFE
Crigler-Najjar syndromeUDP-glucuronosyltransferase
Dubin-Johnson syndromecMOAT
Benign recurrent intrahepatic cholestasisP-type ATPase
Progressive familial Intrahepatic Cholestasis Type 1P-type ATPase
Table 2 HCV non-structural proteins with three-dimensional structures determined and published in the literature
NS3 protease domainProtease that cleaves HCV polyprotein at several locations75, 76
NS4A (complexed to NS3)Cofactor for NS3 protease76
NS3 RNA helicase domainUnwinds viral RNA77, 78