Reduced secretion of epidermal growth factor in duodenal ulcer patients with Helicobacter pylori infection

Table 1 Profile of Helicobacter Pylori infection and basal acid output

Group	n	Symptom duration (> 4 mo)	H. pylori infection				Mucosal active inflammation		Basal acid	output	(mmol/h)
			0	+	+ +	+ + +	corpus	antrum	0-9	2-5	> 5
Con	14	0	12	2	0	0	2	0	0	14	0
CG	27	3	2	9	5	10	27	14	13	9	5
DU	12	3	2	8	1	1	12	4	0	1	11

Con: Healthy volunteers; CG: Chronic gastritis; DU: Duodenal ulcer.

Table 2 Concentration of somatostatin, gastrin and epidermal growth factor in Helicobacter Pylori-positive patients and Helicobacter Pylori-negative healthy volunteers (ng/L)

Group	n	Gastrin	Somatostatin	Epidermal growth factor
		Gastric juice	Gastric juice	Saliva juice	Gastric juice
Con	12	71.2 ± 18.3	105.2 ± 33.5	405.6 ± 35.6	22.0 ± 17.0
CG	25	84.1 ± 24.0	88.6 ± 24.8a	423.0 ± 104.0	22.0 ± 11.1
DU	10	109.2 ± 24.5b	52.4 ± 13.8b	272.0 ± 96.3b	8.3 ± 2.4a

^aP < 0.05,

^bP < 0.01, compared with control group. Con: Healthy volunteers, CG: Chronic gastritis, DU: Duodenal ulcer.