Liver stiffness and perfusion changes for hepatic sinusoidal obstruction syndrome in rabbit model

doi:10.3748/wjg.v26.i7.706

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Feb 21, 2020 (publication date) through Apr 25, 2024

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World Journal of Gastroenterology

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Basic Study

World J Gastroenterol. Feb 21, 2020; 26(7): 706-716
Published online Feb 21, 2020. doi: 10.3748/wjg.v26.i7.706

Table 1 Comparison of laboratory results between control and sinusoidal obstruction syndrome groups

Results	Days	Control group	SOS group	Differences	P value
AST (IU/L)	0	32.67 (-55.57, 120.9)	20.5 (-41.89, 82.89)	12.17 (-95.9, 120.23)	0.818
	3	24.67 (-63.57, 112.9)	23 (-39.39, 85.39)	1.67 (-106.4, 109.73)	0.975
	10	20.67 (-67.57, 108.9)	26.4 (-42.5, 95.3)	-5.73 (-117.68, 106.22)	0.917
	20	26.33 (-61.9, 114.57)	221.34 (130.35, 312.33)	-195.01 (-321.75, -68.26)	0.004^b
ALT (IU/L)	0	38 (3.97, 72.03)	33.17 (9.11, 57.23)	4.83 (-36.84, 46.51)	0.813
	3	44.67 (10.64, 78.69)	41.83 (17.77, 65.89)	2.83 (-38.84, 44.51)	0.890
	10	33.67 (-0.36, 67.69)	25.41 (-1.18, 51.99)	8.26 (-34.92, 51.44)	0.697
	20	40.67 (6.64, 74.69)	109.35 (74.12, 144.58)	-68.69 (-117.67, -19.71)	0.008^b
Tbil (mg/dL)	0	0.27 (-0.18, 0.72)	0.42 (0.1, 0.73)	-0.15 (-0.7, 0.4)	0.579
	3	0.63 (0.18, 1.08)	0.52 (0.2, 0.83)	0.12 (-0.43, 0.67)	0.666
	10	0.9 (0.45, 1.35)	1.18 (0.82, 1.53)	-0.28 (-0.85, 0.29)	0.328
	20	0.53 (0.08, 0.98)	0.96 (0.49, 1.43)	-0.43 (-1.07, 0.22)	0.186
Dbil (mg/dL)	0	0.1 (-0.08, 0.28)	0.12 (-0.01, 0.25)	-0.02 (-0.24, 0.21)	0.879
	3	0.13 (-0.05, 0.32)	0.17 (0.04, 0.3)	-0.03 (-0.26, 0.19)	0.760
	10	0.17 (-0.02, 0.35)	0.26 (0.12, 0.4)	-0.09 (-0.32, 0.14)	0.411
	20	0.13 (-0.05, 0.32)	0.47 (0.28, 0.65)	-0.33 (-0.59, -0.08)	0.013^a

Values are estimated mean and 95% confidence interval.

^aP < 0.05.

^bP < 0.01. SOS: Sinusoidal obstruction syndrome; AST: Serum aspartate aminotransferase; ALT: Alanine aminotransferase; Tbil: Total bilirubin; Dbil: Direct bilirubin.

Table 2 Comparison of quantitative imaging results between control and sinusoidal obstruction syndrome groups

Parameters	Days	Control group	SOS group	Differences	P value
Liver stiffness (kPa)	0	4.35 (2.82, 5.88)	3.89 (2.81, 4.97)	0.46 (-1.41, 2.33)	0.623
	3	5.68 (4.16, 7.21)	6.38 (5.3, 7.45)	-0.69 (-2.56, 1.18)	0.458
	10	4.02 (2.49, 5.54)	9.48 (8.29, 10.66)	-5.46 (-7.39, -3.53)	< 0.001^b
	20	4.67 (3.14, 6.19)	7.71 (6.17, 9.25)	-3.04 (-5.21, -0.87)	0.007^b
VMI 55 keV (HU)	0	153.18 (137.07, 169.29)	158.77 (147.38, 170.16)	-5.59 (-25.33, 14.14)	0.550
	3	147.18 (131.07, 163.29)	167.68 (155.92, 179.44)	-20.5 (-40.44, -0.55)	0.045^a
	10	129.05 (112.94, 145.16)	185.42 (173.62, 197.22)	-56.37 (-76.34, -36.4)	< 0.001^b
	20	148.95 (132.83, 165.06)	179.81 (166.5, 193.11)	-30.86 (-51.69, -10.03)	0.006^b
Iodine concentration (mg/mL)	0	24.8 (20.76, 28.84)	24.2 (21.34, 27.05)	0.61 (-4.34, 5.55)	0.794
	3	20.72 (16.69, 24.76)	26.73 (23.79, 29.67)	-6.01 (-11, -1.02)	0.022^a
	10	19.16 (15.12, 23.19)	31.86 (28.91, 34.8)	-12.7 (-17.7, -7.7)	< 0.001^b
	20	23.85 (19.81, 27.88)	35.14 (31.84, 38.44)	-11.29 (-16.49, -6.1)	< 0.001^b

Values are estimated mean and 95% confidence interval.

^aP < 0.05.

^bP < 0.01. SOS: Sinusoidal obstruction syndrome; VMI: Virtual monochromatic image; HU: Hounsfield unit.

Table 3 Comparison of laboratory results between days 0 and 20

Results	Groups	Day 0	Day 20	Difference	P value
AST (IU/L)	Control	32.67 (-55.57, 120.9)	26.33 (-61.9, 114.57)	6.33 (-118.48, 131.15)	0.916
AST (IU/L)	SOS	20.5 (-41.89, 82.89)	221.34 (130.35, 312.33)	-200.84 (-310.9, -90.78)	0.001^b
ALT (IU/L)	Control	38 (3.97, 72.03)	40.67 (6.64, 74.69)	-2.67 (-51.54, 46.21)	0.910
ALT (IU/L)	SOS	33.17 (9.11, 57.23)	109.35 (74.12, 144.58)	-76.19 (-119.14, -33.24)	0.001^b
Tbil (mg/dL)	Control	0.27 (-0.18, 0.72)	0.53 (0.08, 0.98)	-0.27 (-0.9, 0.37)	0.387
Tbil (mg/dL)	SOS	0.42 (0.1, 0.73)	0.96 (0.49, 1.43)	-0.54 (-1.1, 0.02)	0.057
Dbil (mg/dL)	Control	0.1 (-0.08, 0.28)	0.13 (-0.05, 0.32)	-0.03 (-0.29, 0.22)	0.792
Dbil (mg/dL)	SOS	0.12 (-0.01, 0.25)	0.47 (0.28, 0.65)	-0.35 (-0.57, -0.13)	0.004^b

Values are presented as estimated mean and 95% confidence interval.

^bP < 0.01. SOS: sinusoidal obstruction syndrome; AST: Serum aspartate aminotransferase; ALT: Alanine aminotransferase; Tbil: Total bilirubin; Dbil: Direct bilirubin.

Table 4 Comparison of quantitative imaging results between day 0 and 20

Parameters	Groups	Day 0	Day 20	Difference	P value
Liver stiffness (kPa)	Control	4.35 (2.82, 5.88)	4.67 (3.14, 6.19)	-0.32 (-2.32, 1.69)	0.752
Liver stiffness (kPa)	SOS	3.89 (2.81, 4.97)	7.71 (6.17, 9.25)	-3.82 (-5.61, -2.02)	< 0.001^b
VMI 55 keV (HU)	Control	153.18 (137.07, 169.29)	148.95 (132.83, 165.06)	4.23 (-8.48, 16.95)	0.510
VMI 55 keV (HU)	SOS	158.77 (147.38, 170.16)	179.81 (166.5, 193.11)	-21.04 (-32.7, -9.37)	0.001^b
Iodine concentration (mg/mL)	Control	24.8 (20.76, 28.84)	23.85 (19.81, 27.88)	0.95 (-2.12, 4.03)	0.539
Iodine concentration (mg/mL)	SOS	24.2 (21.34, 27.05)	35.14 (31.84, 38.44)	-10.94 (-13.77, -8.12)	< 0.001^b

Values are presented as estimated mean and 95% confidence interval.

^bP < 0.01. SOS: Sinusoidal obstruction syndrome; VMI: Virtual monochromatic image; HU: Hounsfield unit.

Table 5 Assessment of correlation between final pathologic scores and laboratory results and quantitative imaging parameters

Results	r (95%CI)	P value
AST (IU/L)	0.323 (-0.511, 0.83)	0.453
ALT (IU/L)	0.491 (-0.358, 0.881)	0.230
Tbil (mg/dL)	0.156 (-0.623, 0.771)	0.726
Dbil (mg/dL)	0.261 (-0.557, 0.809)	0.551
Liver stiffness (kPa)	0.635 (-0.171, 0.919)	0.094
VMI 55 keV (HU)	0.587 (-0.241, 0.906)	0.133
Iodine concentration (mg/mL)	0.611 (-0.207, 0.913)	0.112

AST: Serum aspartate aminotransferase; ALT: Alanine aminotransferase; Tbil: Total bilirubin; Dbil: Direct bilirubin; VMI: Virtual monochromatic image; HU: Hounsfield unit; CI: Confidence interval.

Citation: Shin J, Yoon H, Cha YJ, Han K, Lee MJ, Kim MJ, Shin HJ. Liver stiffness and perfusion changes for hepatic sinusoidal obstruction syndrome in rabbit model. World J Gastroenterol 2020; 26(7): 706-716
URL: https://www.wjgnet.com/1007-9327/full/v26/i7/706.htm
DOI: https://dx.doi.org/10.3748/wjg.v26.i7.706