Basic Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Feb 21, 2020; 26(7): 706-716
Published online Feb 21, 2020. doi: 10.3748/wjg.v26.i7.706
Liver stiffness and perfusion changes for hepatic sinusoidal obstruction syndrome in rabbit model
Jaeseung Shin, Haesung Yoon, Yoon Jin Cha, Kyunghwa Han, Mi-Jung Lee, Myung-Joon Kim, Hyun Joo Shin
Jaeseung Shin, Haesung Yoon, Mi-Jung Lee, Myung-Joon Kim, Hyun Joo Shin, Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, Seoul 03722, South Korea
Yoon Jin Cha, Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul 06273, South Korea
Kyunghwa Han, Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Center for Clinical Imaging Data Science, Seoul 03722, South Korea
Author contributions: Shin HJ designed the research; Shin HJ, Shin J, Yoon H and Cha YJ performed the research; Shin HJ and Han K analyzed the data; Shin HJ and Shin J wrote the paper; Shin HJ, Lee M-J, Kim M-J, Yoon H, and Shin J revised and edited manuscript.
Supported by a Faculty Research Grant of Yonsei University College of Medicine for 2017, No. 6-2017-0090.
Institutional animal care and use committee statement: This study was approved by the Institution’s Animal Care and Use Committee of Yonsei University Health System (IACUC approval no. 2017-0174).
Conflict-of-interest statement: Dr. Shin reports grants from Yonsei University College of Medicine, during the conduct of the study.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Hyun Joo Shin, MD, PhD, Clinical Assistant Professor, Department of Radiology, Severance Hospital, Research Institute of Radiological Science, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, South Korea. lamer-22@yuhs.ac
Received: October 29, 2019
Peer-review started: October 29, 2019
First decision: December 23, 2019
Revised: January 8, 2020
Accepted: January 19, 2020
Article in press: January 19, 2020
Published online: February 21, 2020
Core Tip

Core tip: Noninvasive imaging methods are required for the early diagnosis and severity assessment of hepatic sinusoidal obstruction syndrome (SOS). This study showed that liver stiffness on supersonic shear wave imaging was significantly elevated as hepatic SOS progressed in rabbit model. In addition, as hepatic SOS progressed, perfusion parameters measured on dual energy computed tomography were significantly elevated. We suggested that quantitative imaging with supersonic shear wave imaging and dual energy computed tomography could aid in the early diagnosis of hepatic SOS.