Longitudinal decrease in platelet counts as a surrogate marker of liver fibrosis

Table 1 Demographic characteristic of cases with cirrhosis and controls, n (%)

	Cirrhosis (n = 5258)	Control (n = 15774)
Age (yr)	55.91 (15.83), (56, 17-99)	56.04 (16.43), (57, 17-108)
17-30	338 (6.43)	1014 (6.43)
30-40	633 (12.04)	1899 (12.04)
40-50	929 (17.67)	2787 (17.67)
50-60	1215 (23.11)	3645 (23.11)
60-70	1124 (21.38)	3372 (21.38)
70-80	731 (13.9)	2193 (13.9)
80+	288 (5.48)	864 (5.48)
Gender
Female	2866 (54.51)	8598 (54.51)
Male	2392 (45.49)	7176 (45.49)
Country of birth
Africa and Middle East	273 (5.19)	819 (5.19)
America	73 (1.39)	219 (1.39)
Asia	19 (0.36)	57 (0.36)
Europe	2334 (44.39)	7002 (44.39)
Israel	2425 (46.12)	7275 (46.12)
Data N/A	134 (2.55)	402 (2.55)
Diagnosis/sampling year
2001-2004	732 (13.92)	2196 (13.92)
2005-2008	1263 (24.02)	3789 (24.02)
2009-2012	1351 (25.69)	4053 (25.69)
2013-2015	1068 (20.31)	3204 (20.31)
2016-2018	844 (16.05)	2532 (16.05)

Table 2 Comparison between the number of platelets measurements and co-morbidities between cases with cirrhosis and controls, n (%)

	Cirrhosis (n = 5258)	Control (n = 15774)	OR	95%CI
				Low	Up
Platelets measurements	15.59 (14.36) (11, 3-264)	10.69 (10.33) (7, 3-152)	1.033	1.031	1.036
Platelets measurements: 3-10	2510 (47.74)	10482 (66.45)	1
11-20	1409 (26.8)	3395 (21.52)	1.73	1.61	1.87
21+	1339 (25.47)	1897 (12.03)	2.95	2.72	3.20
Diabetes	326 (6.2)	847 (5.37)	1.17	1.02	1.33
HTN	170 (3.23)	447 (2.83)	1.15	0.96	1.37
CKD	390 (7.42)	961 (6.01)	1.24	1.09	1.4
Dyslipidemia	915 (17.4)	2843 (18.02)	0.96	0.88	1.04
Smoking	1563 (29.73)	3470 (22)	1.5	1.398	1.609

HTN: Hypertension; CKD: Chronic kidney disease.

Table 3 Distribution of cirrhosis etiology and complications among cirrhotic patients (n = 5258)

	Frequency	Percent
Etiology
ALD	488	9.28
Viral	987	18.77
Autoimmune	159	3.02
Wilson	9	0.17
NAFLD	413	7.85
Complications
Ascites	450	8.56
Varices	551	10.48
HE	294	5.59
HCC	10	0.19
SBP	118	2.24
Portal HTN	511	9.72
Splenomgally	764	14.53
PVT	70	1.33

ALD: Alcoholic liver disease; NAFLD: Non-alcoholic fatty liver disease; HE: Hepatic encephalopathy; HCC: Hepatocellular carcinoma; SBP: Spontaneous bacterial peritonitis; HTN: Hypertension; PVT: Portal vein thrombosis.