Endogenous motion of liver correlates to the severity of portal hypertension
Sigita Gelman, Romanas Zykus, Irma Kuliavienė, Department of Gastroenterology, Medical Academy, Lithuanian University of Health Sciences, Kaunas 44307, Lithuania
Andrius Sakalauskas, Rytis Jurkonis, Arūnas Lukoševičius, Biomedical Engineering Institute, Kaunas University of Technology, Kaunas 51423, Lithuania
Andrius Pranculis, Department of Radiology, Medical Academy, Lithuanian University of Health Sciences, Kaunas 44307, Lithuania
Limas Kupčinskas, Juozas Kupčinskas, Institute for Digestive Research and Department of Gastroenterology, Medical Academy, Lithuanian University of Health Sciences, Kaunas 44307, Lithuania
Author contributions: Kupcinskas L and Kupcinskas J designed the research; Gelman S, Zykus R and Kuliaviene I treated patients, collected material and clinical data from the patients; Sakalauskas A, Jurkonis R and Lukosevicius A analyzed the radiofrequency signals and developed the algorithm; Pranculis A performed hepatic vein catheterization and HVPG measurement; Gelman S performed ultrasound scanning, analysed the data and drafted the manuscript; Kupcinskas J approved the final version of the manuscript.
Supported by the Research Council of Lithuania, No. S-MIP-19-8; and the Research, Development and Innovation Fund of Kaunas University of Technology, No. MTEPI-L-17003 and MTEPI-L-16012.
Institutional review board statement: The study was reviewed and approved by the Kaunas Region Biomedical Research Ethics Committee (2015-08-24, No. BE-2-28, Kaunas, Lithuania).
Informed consent statement: All study participants provided informed written consent prior to study enrollment.
Conflict-of-interest statement: None declared.
Data sharing statement: Technical appendix and dataset available from the corresponding author at email@example.com. Informed consent for data sharing was not obtained but the presented data are anonymized, and risk of identification is low.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Sigita Gelman, MD, PhD, Assistant Lecturer, Attending Doctor, Department of Gastroenterology, Medical Academy, Lithuanian University of Health Sciences, A. Mickeviciaus Str. 9, Kaunas 44307, Lithuania. firstname.lastname@example.org
Received: May 21, 2020
Peer-review started: May 21, 2020
First decision: May 29, 2020
Revised: June 11, 2020
Accepted: September 17, 2020
Article in press: September 17, 2020
Published online: October 14, 2020