Clinical and Translational Research
Copyright ©The Author(s) 2020.
World J Gastroenterol. Aug 7, 2020; 26(29): 4288-4301
Published online Aug 7, 2020. doi: 10.3748/wjg.v26.i29.4288
Table 1 Baseline characteristics of compensated cirrhosis and hepatitis B virus-associated acute-on-chronic liver failure patients enrolled in Study 1, n (%)
CharacteristicHBV-ACLFControlP value
n234234
Age, yr46.7 ± 10.846.7 ± 10.81.000
Male202 (86.3)202 (86.3)1.000
HBeAg positive98 (41.9)118 (50.4)0.064
HBV-DNA (log10 IU/mL)6.14 (1.85, 8.13)5.95 (1.74, 7.14)0.112
PLT (109/L)120.2 ± 49.1109.6 ± 43.70.014
ALT (IU/L)680 (421, 1191)53 (37,114)< 0.001
AST (IU/L)592 (313, 980)41 (23,60)< 0.001
ALB (g/L)33.6 ± 4.939.9 ± 6.8< 0.001
TBIL (µmol/L)274.1 (166.1, 588.7)17.3 (12.8, 22.5)< 0.001
PTA (%)34 (14, 40)59 (43, 119)< 0.001
INR2.46 ± 0.181.13 ± 0.09< 0.001
BUN (mmol/L)6.1 (3.1, 8.7)4.8 (3.4, 7.2)0.001
Cr (μmol/L)73 (66, 104)68 (51, 89)0.012
SBP124 (53.0)0< 0.001
Hepatic encephalopathy97 (41.5)0< 0.001
Hepatorenal syndrome24 (10.3)0< 0.001
MELD score25.4 ± 4.88.2 ± 3.2< 0.001
Data are presented as the mean ± SD, median (IQR), or n (%). ALB: Albumin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; BUN: Blood urea nitrogen; Cr: Creatinine; HBeAg: Hepatitis B e antigen; HBV-ACLF: hepatitis B virus-associated acute-on-chronic liver failure; INR: International normalized ratio; SBP: Spontaneous bacterial peritonitis; MELD: Model for end-stage liver disease; PLT: Platelet; PTA: Prothrombin activity; TBIL: Total bilirubin level.
Table 2 Characteristics of nutritional and gastrointestinal barrier between survival group and death group in hepatitis B virus-associated acute-on-chronic liver failure patients at admission, n (%)
CharacteristicSurvival groupDeath groupP value
n14391
Male98 (68.53)63 (69.23)0.910
TSF (mm)17.1 ± 5.516.5 ± 5.70.391
SGA score18.1 ± 2.719.8 ± 2.7< 0.001
Fecal cocci-bacillus ratio1.2 ± 0.21.3 ± 0.30.342
D-lactate (μg/mL)13.2 ± 4.014.6 ± 3.80.007
sIgA (mg/L)341.7 ± 95.7371.0 ± 97.90.024
Endotoxin (U/mL)518.0 ± 162.6627.4 ± 179.1< 0.001
IL-1 (μg/mL)86.1 ± 48.5126.8 ± 50.9< 0.001
IL-10 (μg/mL)39 (24, 87)147 (59, 246)< 0.001
TNF-α (pg/mL)53 (21, 104)72 (46, 147)< 0.001
Data presented as mean ± SD or median (IQR). IL-1: Interleukin-1; IL-10: Interleukin-10; SGA: Subjective global assessment; SIgA: Secretory immunoglobulin A; TSF: Triceps skin fold; TNF-α: Tumor necrosis factor alpha.
Table 3 Baseline characteristics of hepatitis B virus-associated acute-on-chronic liver failure patients enrolled in Study 2, n (%)
CharacteristicNutritional supportNone-nutritional supportP value
n234207
Age (yr)46.7 ± 10.847.5 ± 11.60.454
Male202 (86.3)172 (83.9)0.345
HBeAg positive98 (41.9)96 (46.4)0.342
HBV-DNA (log10 IU/mL)6.14 (1.85, 8.13)6.54 (1.53, 8.71)0.097
PLT (109/L)120.2 ± 49.1112.6 ± 52.60.117
ALT (IU/L)680 (421, 1191)652 (447, 1352)0.243
AST (IU/L)592 (313, 980)613 (320, 1014)0.381
ALB (g/L)33.6 ± 4.934.1 ± 5.20.299
TBIL (µmol/L)274.1 (166.1, 588.7)291.5 (162.5, 604.3)0.227
PTA (%)34 (14, 40)32 (11, 40)0.135
INR2.46 ± 0.182.49 ± 0.210.107
BUN (mmol/L)6.1 (3.1, 8.7)6.4 (3.2, 9.2)0.295
Cr (μmol/L)73 (66, 104)76 (59, 98)0.530
SBP124 (53.0)106 (51.2)0.708
Hepatic encephalopathy97 (41.5)82 (39.6)0.695
Hepatorenal syndrome24 (10.3)19 (9.2)0.703
MELD scores25.4 ± 4.826.1 ± 5.20.142
Artificial extracorporeal liver support141 (60.3)124 (59.9)0.940
Data presented as mean ± SD, median (IQR) or n (%). ALB: Albumin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; BUN: Blood urea nitrogen; Cr: Creatinine; HBeAg: Hepatitis B e antigen; INR: International normalized ratio; SBP: Spontaneous bacterial peritonitis; MELD: Model for end-stage liver disease; PLT: Platelet; PTA: Prothrombin activity; TBIL: Total bilirubin level.