Review
Copyright ©The Author(s) 2020.
World J Gastroenterol. Jun 14, 2020; 26(22): 2902-2915
Published online Jun 14, 2020. doi: 10.3748/wjg.v26.i22.2902
Table 1 The earliest classification system of drug-induced pancreatitis, as proposed by Trivedi et al[16]
Class IClass IIClass III
≥ 1 case documenting a positive re-challengeWith or without drug re-challengeAll drugs associated with drug induced pancreatitis
≥ 20 case reports10-20 case reports< 10 case reports
Table 2 The more recent classification system of drug-induced pancreatitis, proposed by Badalov et al[13]
Minimum No. of case reportsRe-challenge requiredLatency establishedAlternative causes of pancreatitis excluded
Class Ia1YesN/AYes
Class Ib1YesN/ANo
Class II4NoYes1N/A
Class III2NoNoN/A
Class IV1NoNoN/A
Table 3 Classes of medications implicated in drug-induced pancreatitis grouped according to the three-class system of classification
Class IClass IIClass III
AminosalicylatesAlkylating antineoplasticsAminosalicylates
AnticonvulsantsAngiotensin-converting enzyme inhibitorsAntacids
Antimetabolite antineoplasticsAnticonvulsantsAntiarrhythmics
AntimicrobialsAntimicrobialsAntibacterials
Hormone replacement therapiesAntitubercular agentsAnticholinesterases
Loop diureticsInterferonsAnticonvulsants
Non-biologic immunosuppressivesNonopioid analgesicsAntidepressants
Nonsteroidal anti-inflammatoriesReverse transcriptase inhibitorsAntifungals
OpiatesSomatostatin analogsAntihypertensives
Reverse transcriptase inhibitorsThiazidesAntimetabolite antineoplastics
SteroidsAntineoplastics
Antiplatelets
Antivirals
Atypical antipsychotics
Cholesterol lowering agents
Cyclooxygenase II inhibitors
Estrogens
Immunomodulators
Nonsteroidal anti-inflammatories
Parasympathetic agents
Proton pump inhibitors
Selective serotonin agonists
Somatostatin analogs
Steroids
TNF-alpha inhibitors
Vitamins