Observational Study
Copyright ©The Author(s) 2018.
World J Gastroenterol. Feb 14, 2018; 24(6): 752-762
Published online Feb 14, 2018. doi: 10.3748/wjg.v24.i6.752
Table 1 Patients’ demographic data and characteristics mean ± SD or n (%)
CharacteristicsAll participants (n = 50)
Age (yr)6.67 ± 4.63
Age at liver transplantation (yr)3.06 ± 3.97
Gender - female27 (54)
Before liver transplantation
Anti-HBs level (IU/L)584.41 ± 415.45
Anti-HBc positive1 (2)
After liver transplantation
Anti-HBs level (IU/L)58.56 ± 6.40
Length of stay in hospital after transplant (d)44.10 ± 29.30
ABO incompatibility3 (6)
PELD/MELD score18.38 ± 8.47/15 (11-19)
Time since transplantation (yr)2.53 ± 2.11
Medical complications
Acute rejection22 (44)
Cytomegalovirus infection15 (30)
Posttransplant lymphoproliferative disorder14 (28)
De novo hepatitis B infection1 (2)
De novo food allergy9 (18)
Surgical complications
Vascular stricture20 (40)
Biliary stricture12 (24)
Chylous ascites/chylothorax7 (14)
Donor characteristics
Gender - female22 (44)
Cadaveric6 (12)
Living44 (88)
Anti-HBs
Negative13 (26)
Positive
1-9 IU/L30 (60)
> 10 IU/L7 (14)
Anti-HBc positive6 (12)
Table 2 Nutritional and laboratory results of pre and post liver transplantation mean ± SD or n (%)
Pre-transplantationPost-transplantation
P value
Short-term (3 mo)Long-term
Body weight (kg)11.66± 8.01-21.32 ± 12.07< 0.001
Height (meter)0.81 ± 0.23-1.07 ± 0.28< 0.001
BMI (kg/m2)16.59 ± 1.67-16.63 ± 2.710.76
Complete blood count
White blood cell (/μL)10492 ± 46278559 ± 24957729 ± 38430.002
Neutrophil (/μL)4938 ± 25653385 ± 16793418 ± 1912< 0.001
Lymphocyte (/μL)4263 ± 22223982 ± 17223109 ± 17620.01
Platelet (/μL)172880 ± 94557199720 ± 82777233957 ± 941360.005
Liver function test
Total bilirubin(mg/dL)18.50 ± 12.682.41 ± 0.910.84 ± 0.91< 0.001
Direct bilirubin (mg/dL)13.41 ± 10.280.83 ± 0.710.38 ± 0.51< 0.001
Albumin (g/dL)3.29 ± 0.973.94 ± 0.484.08 ± 0.35< 0.001
Number of immunosuppressant
001 (2)
15 (10)27 (54)< 0.001
223 (46)17 (34)
322 (44)5 (10)
Table 3 Potential factors associated with immunity in participants with HBV immunity and immunity loss mean ± SD or n (%)
Nonimmunity (n = 30)Immunity (n = 20)P value
Age (yr)7.60 ± 4.985.27 ± 3.740.08
Age at liver transplantation (yr)3.71 ± 4.782.09 ± 2.030.11
Gender:Female15 (50)12 (60)0.58
Body weight (kg)13.07 ± 9.919.56 ± 2.740.07
Height (m)0.85 ± 0.280.75 ± 0.120.09
Body mass index (kg/m2)16.45 ± 1.6216.45 ± 1.620.47
Anti-HBs level before transplantation (IU/L)441.39 ± 408.88798.94 ± 330.470.24
Length of hospital stay after transplantation (d)47.77 ± 34.8938.80 ± 17.450.24
PELD/MELD score20.19 ± 8.50 (n = 28)15.90 ± 7.98 (n = 19)0.09
Time since transplant to anti-HBs testing (yr)2.83 ± 2.002.06 ± 2.220.22
Donor characteristics
Gender: Female14 (47)8 (40)0.43
Living26 (87)18 (90)0.54
Medical complication
Acute rejection11 (37)11 (55)0.16
CMV infection6 (20)9 (45)0.11
PTLD7 (23)7 (35)0.28
De novo hepatitis B1 (3)0 (0)0.65
De novo food allergy5 (16)4 (20)0.52
Surgical complication
Vascular stricture13 (43)7 (35)0.39
Biliary stricture8 (27)4 (20)0.46
Chylous ascites/chylothorax5 (17)2 (10)0.41
Laboratory data before transplantation
White blood cell (/µL)10237 ± 416710875 ± 53340.63
Neutrophil (/µL)4780 ± 21375174 ± 31450.60
Lymphocyte (/µL)4372 ± 25154100 ± 17420.65
Platelet (/µL)159366 ± 99431193156 ± 851320.22
Total bilirubin (mg/dL)22.80 ± 13.7212.04 ± 7.370.003
Direct bilirubin (mg/dL)16.51 ± 11.378.73 ± 6.080.001
Albumin (g/dL)3.07 ± 0.653.63 ± 1.250.04
Laboratory data 3 mo after transplantation
White blood cell (/µL)8312 ± 25968931 ± 34400.64
Neutrophil (/µL)3221 ± 13073630 ± 21360.45
Lymphocyte (/µL)3879 ± 18514136 ± 15420.61
Platelet (/µL)193300 ± 86221208600 ± 785910.53
Albumin (g/dL)3.96 ± 0.513.91 ± 0.440.72
Total bilirubin (mg/dL)0.99 ± 1.120.59 ± 0.350.07
Direct bilirubin (mg/dL)0.37 ± 0.150.32 ± 0.170.12
Laboratory data after long-term transplantation
White blood cell (/µL)7114 ± 28458815 ± 50830.22
Neutrophil (/µL)3196 ± 14123809 ± 25760.38
Lymphocyte (/µL)3039 ± 15533232 ± 21280.72
Platelet (/µL)217033 ± 87395263823 ± 1007390.12
Albumin (g/dL)4.12 ± 0.354.00 ± 0.350.26
Total bilirubin (mg/dL)0.98 ± 1.101.10 ± 0.310.08
Direct bilirubin (mg/dL)0.45 ± 0.620.25 ± 0.130.20
Immunosuppressant 3 mo after transplantation
None00
13 (10)2 (10)0.41
216 ((53)7 (35)
311 (37)11 (50)
Immunosuppressant after long-term liver transplantation
None1 (3)0
117 (56)10 (50)0.77
29 (30)8 (40)
33 (10)2 (10)