Copyright
©The Author(s) 2018.
World J Gastroenterol. Feb 14, 2018; 24(6): 752-762
Published online Feb 14, 2018. doi: 10.3748/wjg.v24.i6.752
Published online Feb 14, 2018. doi: 10.3748/wjg.v24.i6.752
Characteristics | All participants (n = 50) |
Age (yr) | 6.67 ± 4.63 |
Age at liver transplantation (yr) | 3.06 ± 3.97 |
Gender - female | 27 (54) |
Before liver transplantation | |
Anti-HBs level (IU/L) | 584.41 ± 415.45 |
Anti-HBc positive | 1 (2) |
After liver transplantation | |
Anti-HBs level (IU/L) | 58.56 ± 6.40 |
Length of stay in hospital after transplant (d) | 44.10 ± 29.30 |
ABO incompatibility | 3 (6) |
PELD/MELD score | 18.38 ± 8.47/15 (11-19) |
Time since transplantation (yr) | 2.53 ± 2.11 |
Medical complications | |
Acute rejection | 22 (44) |
Cytomegalovirus infection | 15 (30) |
Posttransplant lymphoproliferative disorder | 14 (28) |
De novo hepatitis B infection | 1 (2) |
De novo food allergy | 9 (18) |
Surgical complications | |
Vascular stricture | 20 (40) |
Biliary stricture | 12 (24) |
Chylous ascites/chylothorax | 7 (14) |
Donor characteristics | |
Gender - female | 22 (44) |
Cadaveric | 6 (12) |
Living | 44 (88) |
Anti-HBs | |
Negative | 13 (26) |
Positive | |
1-9 IU/L | 30 (60) |
> 10 IU/L | 7 (14) |
Anti-HBc positive | 6 (12) |
Pre-transplantation | Post-transplantation | P value | ||
Short-term (3 mo) | Long-term | |||
Body weight (kg) | 11.66± 8.01 | - | 21.32 ± 12.07 | < 0.001 |
Height (meter) | 0.81 ± 0.23 | - | 1.07 ± 0.28 | < 0.001 |
BMI (kg/m2) | 16.59 ± 1.67 | - | 16.63 ± 2.71 | 0.76 |
Complete blood count | ||||
White blood cell (/μL) | 10492 ± 4627 | 8559 ± 2495 | 7729 ± 3843 | 0.002 |
Neutrophil (/μL) | 4938 ± 2565 | 3385 ± 1679 | 3418 ± 1912 | < 0.001 |
Lymphocyte (/μL) | 4263 ± 2222 | 3982 ± 1722 | 3109 ± 1762 | 0.01 |
Platelet (/μL) | 172880 ± 94557 | 199720 ± 82777 | 233957 ± 94136 | 0.005 |
Liver function test | ||||
Total bilirubin(mg/dL) | 18.50 ± 12.68 | 2.41 ± 0.91 | 0.84 ± 0.91 | < 0.001 |
Direct bilirubin (mg/dL) | 13.41 ± 10.28 | 0.83 ± 0.71 | 0.38 ± 0.51 | < 0.001 |
Albumin (g/dL) | 3.29 ± 0.97 | 3.94 ± 0.48 | 4.08 ± 0.35 | < 0.001 |
Number of immunosuppressant | ||||
0 | 0 | 1 (2) | ||
1 | 5 (10) | 27 (54) | < 0.001 | |
2 | 23 (46) | 17 (34) | ||
3 | 22 (44) | 5 (10) |
Nonimmunity (n = 30) | Immunity (n = 20) | P value | |
Age (yr) | 7.60 ± 4.98 | 5.27 ± 3.74 | 0.08 |
Age at liver transplantation (yr) | 3.71 ± 4.78 | 2.09 ± 2.03 | 0.11 |
Gender:Female | 15 (50) | 12 (60) | 0.58 |
Body weight (kg) | 13.07 ± 9.91 | 9.56 ± 2.74 | 0.07 |
Height (m) | 0.85 ± 0.28 | 0.75 ± 0.12 | 0.09 |
Body mass index (kg/m2) | 16.45 ± 1.62 | 16.45 ± 1.62 | 0.47 |
Anti-HBs level before transplantation (IU/L) | 441.39 ± 408.88 | 798.94 ± 330.47 | 0.24 |
Length of hospital stay after transplantation (d) | 47.77 ± 34.89 | 38.80 ± 17.45 | 0.24 |
PELD/MELD score | 20.19 ± 8.50 (n = 28) | 15.90 ± 7.98 (n = 19) | 0.09 |
Time since transplant to anti-HBs testing (yr) | 2.83 ± 2.00 | 2.06 ± 2.22 | 0.22 |
Donor characteristics | |||
Gender: Female | 14 (47) | 8 (40) | 0.43 |
Living | 26 (87) | 18 (90) | 0.54 |
Medical complication | |||
Acute rejection | 11 (37) | 11 (55) | 0.16 |
CMV infection | 6 (20) | 9 (45) | 0.11 |
PTLD | 7 (23) | 7 (35) | 0.28 |
De novo hepatitis B | 1 (3) | 0 (0) | 0.65 |
De novo food allergy | 5 (16) | 4 (20) | 0.52 |
Surgical complication | |||
Vascular stricture | 13 (43) | 7 (35) | 0.39 |
Biliary stricture | 8 (27) | 4 (20) | 0.46 |
Chylous ascites/chylothorax | 5 (17) | 2 (10) | 0.41 |
Laboratory data before transplantation | |||
White blood cell (/µL) | 10237 ± 4167 | 10875 ± 5334 | 0.63 |
Neutrophil (/µL) | 4780 ± 2137 | 5174 ± 3145 | 0.60 |
Lymphocyte (/µL) | 4372 ± 2515 | 4100 ± 1742 | 0.65 |
Platelet (/µL) | 159366 ± 99431 | 193156 ± 85132 | 0.22 |
Total bilirubin (mg/dL) | 22.80 ± 13.72 | 12.04 ± 7.37 | 0.003 |
Direct bilirubin (mg/dL) | 16.51 ± 11.37 | 8.73 ± 6.08 | 0.001 |
Albumin (g/dL) | 3.07 ± 0.65 | 3.63 ± 1.25 | 0.04 |
Laboratory data 3 mo after transplantation | |||
White blood cell (/µL) | 8312 ± 2596 | 8931 ± 3440 | 0.64 |
Neutrophil (/µL) | 3221 ± 1307 | 3630 ± 2136 | 0.45 |
Lymphocyte (/µL) | 3879 ± 1851 | 4136 ± 1542 | 0.61 |
Platelet (/µL) | 193300 ± 86221 | 208600 ± 78591 | 0.53 |
Albumin (g/dL) | 3.96 ± 0.51 | 3.91 ± 0.44 | 0.72 |
Total bilirubin (mg/dL) | 0.99 ± 1.12 | 0.59 ± 0.35 | 0.07 |
Direct bilirubin (mg/dL) | 0.37 ± 0.15 | 0.32 ± 0.17 | 0.12 |
Laboratory data after long-term transplantation | |||
White blood cell (/µL) | 7114 ± 2845 | 8815 ± 5083 | 0.22 |
Neutrophil (/µL) | 3196 ± 1412 | 3809 ± 2576 | 0.38 |
Lymphocyte (/µL) | 3039 ± 1553 | 3232 ± 2128 | 0.72 |
Platelet (/µL) | 217033 ± 87395 | 263823 ± 100739 | 0.12 |
Albumin (g/dL) | 4.12 ± 0.35 | 4.00 ± 0.35 | 0.26 |
Total bilirubin (mg/dL) | 0.98 ± 1.10 | 1.10 ± 0.31 | 0.08 |
Direct bilirubin (mg/dL) | 0.45 ± 0.62 | 0.25 ± 0.13 | 0.20 |
Immunosuppressant 3 mo after transplantation | |||
None | 0 | 0 | |
1 | 3 (10) | 2 (10) | 0.41 |
2 | 16 ((53) | 7 (35) | |
3 | 11 (37) | 11 (50) | |
Immunosuppressant after long-term liver transplantation | |||
None | 1 (3) | 0 | |
1 | 17 (56) | 10 (50) | 0.77 |
2 | 9 (30) | 8 (40) | |
3 | 3 (10) | 2 (10) |
- Citation: Sintusek P, Posuwan N, Wanawongsawad P, Jitraruch S, Poovorawan Y, Chongsrisawat V. High prevalence of hepatitis B-antibody loss and a case report of de novo hepatitis B virus infection in a child after living-donor liver transplantation. World J Gastroenterol 2018; 24(6): 752-762
- URL: https://www.wjgnet.com/1007-9327/full/v24/i6/752.htm
- DOI: https://dx.doi.org/10.3748/wjg.v24.i6.752