Ubiquitin-proteasome system and oxidative stress in liver transplantation

Table 1 Effect of different proteasome inhibitors on organ preservation

Inhibitor	Organ and condition	Manifestations	Ref.
PS-519	Heart after IRI (rat)	Improved cardiac contractility	Campbell et al[99]
		Improved coronary flow
		Reduced PMN infiltration
Epoxomicin	Heart after cold ischemia (rat)	Reduced edema formation	Geng et al[70]
		Preserved ultrastructural integrity
MG132	Liver, warm IRI (rat)	Decreased LDH and ALT	Alexandrova et al[4]
		Increased protein oxidation
		Decreased antioxidant activities
MG132	Liver, cold IRI (rat)	Decreased AST and ALT	Zaouali et al[71]
		Reduced inflammation (IL1β and TNFα)
Bortezomid	Liver, cold IRI (rat)	Decreased AST, ALT and mitochondrial damage	Zaouali et al[71]
		Increased bile production	Bejaoui et al[72]
		Decreased lipid peroxidation
		Decreased apoptosis (Cyt C and Caspase 3)

IRI: Ischemia-reperfusion injury.