Characteristics and predictors of gastric cancer after Helicobacter pylori eradication

Table 1 Endoscopic and histological characteristics of gastric cancer after Helicobacter pylori eradication

Ref.	Number of gastric cancer after eradication/during infection	Study design	Case recruitment	Characteristics
Shichijo et al[31]	21/NA	Case series	Surveillance	Intestinal type
Maehata et al[42]	96/96	Propensity score-matched study	ESD cases	Depressed
Nishizawa et al[43]	34/NA	Case series	Surveillance	Depressed, intestinal type, relatively small
Matsuo et al[44]	26/78	Case control study	Surveillance	Male, intestinal type, flat-depressed, low MUC2 and Wnt5a
Yamamoto et al[45]	18/36	Case control study	Early stage cancer	Smaller, lower Ki-67 index, depression, complete gastric type or gastric predominant mixed type
Horiguchi et al[48]	71/115	Case control study	Case series	Non-tumorous epithelium Surface differentiation
Ito et al[52]	29/NA	Case series	ESD cases	Normal columnar epithelium
Kitamura et al[53]	27/27	Case control study	Endoscopic resection cases	Low-grade atypia on the surface
Hori et al[54]	59/152	Case control study	Endoscopic resection cases	Non-neoplastic epithelium, flattening of tumors, muting of the whitish discoloration

NA: Not applicable; ESD: Endoscopic submucosal dissection.

Table 2 Risk factor of gastric cancer development after Helicobacter pylori eradication

Ref.	Subject number	Study design	Diagnosis	Age	Follow-up period (yr)	Number of cancer	Risk factor
Shichijo et al[31]	573	Cohort study	CG/DU/GU	58	6.4	21	Endoscopic severe atrophy
							Histologic intestinal metaplasia
Take et al[32]	1674	Cohort study	GU/DU	51	5.6	28	Endoscopic severe atrophy
Toyoshima et al[55]	1232	Cohort study	CG/DU/GU	54	2.5	15	Endoscopic severe atrophy
Sakitani et al[56]	965	Cohort study	CG/DU/GU	63	4.5	21	Endoscopic severe atrophy
Cheung et al[57]	63397	Cohort study	Helicobacter pylori infection (GU 2%, DU 3%)	55	7.6	153	Proton pump inhibitor
Takata et al[58]	101	Cohort study	CG/GU/GC	56	5.3	8	Age
Kodama et al[59]	2355	Matched control study	CG/DU/GU/GC	63	4.1	21	Endoscopic severe atrophy
							OLGA staging
							Histologic atrophy at the antrum
							Histologic inflammation at the corpus
							Histologic intestinal metaplasia at the corpus
Sugimoto et al[60]	1200	Cross- sectional study	NA	70	4.6	79	Endoscopic severe atrophy
Haneda et al[62]	261	Cross sectional study	CG/DU/GU/GC/MALToma/hyperplastic polyp	57	NA	47	Pepsinogen I/II ratio ≤ 4.5
Maeda et al[63]	177	Cross sectional study	NA	NA	NA	94	Epigenetic marker

GU: Gastric ulcer; DU: Duodenal ulcer; CG: Chronic gastritis; GC: Gastric cancer; NA: Not available.