Prospective Study
Copyright ©The Author(s) 2017.
World J Gastroenterol. May 21, 2017; 23(19): 3530-3537
Published online May 21, 2017. doi: 10.3748/wjg.v23.i19.3530
Table 1 Demographic and clinical details of patients n (%)
VariablesUC (n = 139)CD (n = 117)P value
Age: yr, median (range)43 (16-70)32 (17-60)< 0.001
Sex, Male83 (59.7)81 (69.2)0.11
Education10.04
Junior (education to age 16)9 (8.5)2 (1.9)
Graduate (education to age 19)35 (33.0)28 (26.9)
Third level education62 (58.5)74 (71.2)
Family history211 (10.3)4 (3.9)0.07
Smoking status30.25
Non-smoker64 (60.4)64 (63.4)
Ex-smoker33 (31.1)23 (22.8)
Smoker9 (8.5)14 (13.9)
Disease duration: years, median (range)6.3 (0.1-26.2)5.2 (0.1-14.9)0.06
Disease location
Proctitis (UC)/colon (CD)39 (28.1)27 (23.1)
Left sided (UC)/small bowel (CD)47 (33.8)27 (23.1)
Pancolitis (UC)/colon+Small bowel (CD)53 (38.1)63 (53.8)
Disease activity0.16
Remission82 (59.0)81/117 (69.2)
Mild42 (30.2)21/117 (17.9)
Moderate14 (10.1)14/117 (11.9)
Severe1 (0.7)1/117 (0.8)
Previous surgery419 (18.6)34 (33.3)0.02
Medication
Azathioprine/6-mercaptopurine33 (23.7)72 (61.5)< 0.001
Anti-TNF17 (12.2)31 (26.7)0.003
Table 2 Spearman correlations (rs) between short health scale items and inflammatory bowel disease questionnaire dimensions
Symptoms rsActivities rsWorry rsWell-being rsTotal score rs
Crohn’s disease
IBDQ bowel symptoms-0.66-0.54-0.45-0.52
IBDQ social function-0.50-0.71-0.5-0.46
IBDQ emotional function-0.49-0.59-0.64-0.67
IBDQ systemic symptoms-0.60-0.61-0.51-0.65
Total score-0.81
Ulcerative colitis
IBDQ bowel symptoms-0.68-0.52-0.49-0.55
IBDQ social function-0.55-0.71-0.59-0.56
IBDQ emotional function-0.47-0.59-0.62-0.62
IBDQ systemic symptoms-0.45-0.56-0.50-0.52
Total score-0.71
Table 3 Responsiveness to change in disease activity in the short health scale
Stable remission (n = 67)Change in disease activity (n = 21)
SHSRemissionRemissionRemissionMild to moderate
Symptoms4 (0-35)7 (0-50)8.5 (5-45)15 (2-50)
Activities3.5 (0-70)8 (0-60)10 (0-70)8.5 (0-60)
Worry17.5 (0-100)7.5 (0-100)a20 (7-70)27 (7-60)
Well-being8.5 (0-55)6 (0-90)17.5 (3-80)30 (0-60)
Total score40 (0-205)40 (0-210)59 (24-265)87 (20-230)
Table 4 Influence of other demographic and disease factors on high short health scale score
SymptomsActivityWorryWell-being
Age < 40 (vs ≥ 40)2.76 (0.79-9.56)3.53 (1.18-10.56)1.06 (0.47-3.28)1.67 (0.70-3.94)
Sex, Female (vs male)0.85 (0.25-2.90)3.70 (0.98-7.45)1.79 (0.83-3.85)2.28 (1.02-5.08)
Education, beyond high school (vs junior school)0.33 (0.02-5.51)1.73 (0.25-11.95)4.74 (1.06-21.2)1.31 (0.22-7.75)
Smoking (vs non or ex-smoking)3.79 (0.86-16.43)3.43 (0.92-12.77)1.02 (0.33-3.16)2.78 (0.94-8.21)
Family history (vs no)0.34 (0.06-1.92)1.93 (0.20-18.62)0.50 (0.14-1.80)0.41 (0.10-1.59)
Disease, CD (vs UC)0.54 (0.15-1.91)0.52 (1.17-1.54)0.81 (0.35-1.88)1.41 (0.58-3.43)
Disease duration ≥ 5 yr (vs < 5 yr)1.33 (0.45-3.89)2.12 (0.81-5.52)2.98 (1.43-6.20)1.62 (0.77-3.45)
Anti-TNF use (vs no)0.81 (0.18-3.59)1.69 (0.53-5.44)2.56 (1.06-6.22)1.01 (0.48-2.68)
Azathioprine use (vs no)0.55 (0.16-1.91)1.39 (0.49-3.94)1.39 (0.62-3.08)1.69 (0.72-3.96)
Bowel operation history (vs no)1.19 (0.28-4.94)1.80 (0.50-6.47)0.91 (0.40-2.06)1.09 (0.44-2.68)
Disease activity, moderate to severe (vs mild or remission)16.6 (4.19-66.18)8.02 (2.43-26.43)12.56 (3.66-43.09)6.03 (1.98-18.40)