Clinical Trials Study
Copyright ©The Author(s) 2017.
World J Gastroenterol. May 7, 2017; 23(17): 3133-3141
Published online May 7, 2017. doi: 10.3748/wjg.v23.i17.3133
Table 1 The pathological stage of hepatic fibrosis
StageDescriptionCriteria
S0No fibrosisNormal connective tissue
S1Portal fibrosisFibrous portal expansion
S2Periportal fibrosisPeriportal or rare portal-portal septa
S3Septal fibrosisFibrous septa with architectural distortion; no obvious cirrhosis
S4Early cirrhosisCirrhosis
Table 2 The pathological grade of hepatitis
GradeDescriptionCriteria
G0No activityNo lobular inflammation and necrosis
G1Minimal activityMinimal, occasional spotty necrosis
G2Mild activityMild, little hepatocellular damage
G3Moderate activityModerate, noticeable hepatocellular change
G4Severe activitySevere, prominent diffuse hepatocellular damage
Table 3 Pathogeny statistics
PathogenyNumberPercent
Chronic hepatitis B4761.80%
Primary biliary cirrhosis1013.20%
Non-alcoholic fatty liver disease56.60%
Chronic drug hepatitis45.30%
Autoimmune hepatitis22.60%
Alcoholic fatty liver disease22.60%
Chronic hepatitis EB22.60%
Hemochromatosis11.30%
Hyperthyroid liver damage11.30%
Hyperbilirubinemia11.30%
Portal hypertension11.30%
Table 4 Relative enhancement ratio in the hepatocyte phase in the five stages of hepatic fibrosis
StageREh (mean ± SD)Minimum valueMaximum value
S0 (n = 16)0.450 ± 0.1950.1290.698
S1 (n = 15)0.460 ± 0.1760.1780.715
S2 (n = 21)0.542 ± 0.2040.2291.006
S3 (n = 9)0.364 ± 0.1770.3230.621
S4 (n = 15)0.411 ± 0.1840.1840.836
Table 5 Relative enhancement ratio in the hepatocyte phase in the five grades of hepatitis
GradeREh (mean ± standard)Minimum valueMaximum value
G1 (n = 44)0.505 ± 0.1940.1291.006
G2 (n = 22)0.402 ± 0.1900.0330.836
G3 (n = 8)0.428 ± 0.1470.1820.621
G4 (n = 2)0.209 ± 0.1700.1970.221
Table 6 Correlation of relative enhancement ratio in the hepatocyte phase with serologic liver functional parameters
VariableMeanSDRangeCoefficient factorP value
TB43.5280.814.2-484.7-0.34620.002
PT (s)12.131.820.9-16.8-0.1300.263
ALB (g/L)39.736.3116.0-66.40.1400.227
ALT (U/L)124.45166.4416-939-0.29010.011
AST (U/L)63.4660.4714-351-0.29920.009