Gutuo Jiejiu decoction improves survival of patients with severe alcoholic hepatitis: A retrospective cohort study

Table 1 Baseline characteristics

Characteristic	Observation group	Controlgroup	P value
Age (yr)	50.50 ± 9.84	52.18 ± 10.31	0.347
Alcohol intake (g/d)	142.60 ± 46.00	140.72 ± 42.95	0.994
Leukocytes (× 109/L)	6.36 ± 3.35	5.55 ± 1.86	0.207
Neutrophils (× 109/L)	4.21 ± 2.60	3.58 ± 1.35	0.158
Hemoglobin (g/L)	102.49 ± 23.90	107.75 ± 16.46	0.249
Platelets (× 109/L)	88.00 ± 39.91	83.35 ± 28.20	0.613
Blood urea nitrogen (mmol/L)	11.86 ± 2.19	12.26 ± 2.20	0.232
Sodium (mmol/L)	135.93 ± 8.31	136.18 ± 5.56	0.616
Albumin (g/L)	29.27 ± 5.97	30.34 ± 5.75	0.303
Total bilirubin (μmol/L)	89.73 ± 33.50	95.49 ± 47.97	0.727
Alanine aminotransferase (U/L)	76.41 ± 27.06	85.72 ± 28.86	0.055
Aspartate aminotransferase (U/L)	173.04 ± 74.21	185.15 ± 71.61	0.225
Gamma glutamyl transpeptidase (U/L)	148.40 ± 88.04	159.42 ± 84.30	0.301
Prothrombin time (s)	21.69 ± 1.50	21.46 ± 1.76	0.173
International normalized ratio	1.92 ± 0.13	1.95 ± 0.16	0.173
Maddrey’s discriminant function	40.63 ± 6.69	39.97 ± 7.72	0.226
Child-Turcotte-Pugh	10.56 ± 1.36	10.40 ± 1.26	0.555

Table 2 Characteristics after treatment (3 mo)

Characteristic	Observation group	Controlgroup	P value
Leukocytes (× 109/L)	5.60 ± 1.03	5.52 ± 0.98	0.748
Neutrophils (× 109/L)	4.13 ± 0.68	4.20 ± 0.75	0.652
Hemoglobin (g/L)	116.57 ± 12.81	111.22 ± 13.39	0.087
Platelets (× 109/L)	107.82 ± 17.45	108.37 ± 12.13	0.521
Blood urea nitrogen (mmol/L)	5.95 ± 1.52	7.57 ± 1.76	0.000
Sodium (mmol/L)	126.15 ± 8.74	125.64 ± 10.32	0.828
Albumin (g/L)	34.86 ± 4.36	32.79 ± 4.39	0.048
Total bilirubin (μmol/L)	56.11 ± 19.13	67.49 ± 19.70	0.016
Alanine aminotransferase (U/L)	63.79 ± 17.16	77.81 ± 16.75	0.001
Aspartate aminotransferase (U/L)	83.93 ± 19.92	92.48 ± 20.24	0.076
Gamma glutamyl transpeptidase (U/L)	78.29 ± 15.14	86.04 ± 14.96	0.032
Prothrombin time (s)	17.46 ± 1.85	18.59 ± 2.26	0.038
International normalized ratio	1.59 ± 0.17	1.69 ± 0.21	0.038
Maddrey’s discriminant function	19.22 ± 8.84	25.07 ± 10.59	0.014
Child-Turcotte-Pugh	8.52 ± 1.50	9.89 ± 1.97	0.002

Table 3 Characteristics after treatment (12 mo)

Characteristic	Observation group	Control group	P value
Leukocytes (× 109/L)	5.18 ± 0.99	5.89 ± 0.95	0.029
Neutrophils (× 109/L)	3.52 ± 0.74	3.98 ± 0.54	0.018
Hemoglobin (g/L)	125.54 ± 12.38	118.69 ± 10.36	0.045
Platelets (× 109/L)	120.65 ± 19.10	105.23 ± 20.31	0.009
Blood urea nitrogen (mmol/L)	4.39 ± 0.87	5.74 ± 2.09	0.049
Sodium (mmol/L)	134.12 ± 5.43	128.72 ± 5.36	0.005
Albumin (g/L)	38.77 ± 4.76	34.10 ± 4.55	0.005
Total bilirubin (μmol/L)	37.71 ± 14.53	47.44 ± 13.44	0.015
Alanine aminotransferase (U/L)	49.23 ± 18.41	58.77 ± 15.00	0.040
Aspartate aminotransferase (U/L)	42.10 ± 11.96	51.31 ± 17.61	0.042
Gamma glutamyl transpeptidase (U/L)	53.75 ± 15.95	66.38 ± 17.87	0.022
Prothrombin time (s)	16.41 ± 1.81	18.23 ± 2.77	0.047
International normalized ratio	1.50 ± 0.17	1.66 ± 0.25	0.047
Maddrey’s discriminant function	13.90 ± 8.65	22.24 ± 12.77	0.017
Child-Turcotte-Pugh	7.46 ± 1.35	9.15 ± 1.63	0.001