MicroRNA profiling of the intestine during hypothermic circulatory arrest in swine

Table 1 MicroRNAs that were dysregulated in the hypothermic circulatory arrest group vs the sham operation group

	Up-regulation	FC	P value	Down-regulation	FC	P value
1	miR-122	5.37	0.0193	let-7d-3p	8.73	0.0000
2	miR-542-5p	2.64	0.0273	miR-31	2.33	0.0141
3	miR-499-3p	2.47	0.0026	miR-221-5p	2.18	0.0248
4	miR-421-5p	2.41	0.0141	miR-4333	2.01	0.0219
5	miR-4334-5p	1.95	0.0344	miR-29b	1.89	0.0213
6	miR-345-3p	1.73	0.0212	miR-196b-3p	1.79	0.0440
7	miR-181d-3p	1.63	0.0211	miR-192	1.63	0.0494
8	miR-2483	1.59	0.0074	miR-664-3p	1.55	0.0085
9	miR-125a	1.52	0.0487	miR-342	1.49	0.0266
10	miR-874	1.48	0.0226	miR-130a	1.40	0.0006
11	miR-299	1.47	0.0440
12	miR-34a	1.41	0.0489
13	miR-331-3p	1.38	0.0392
14	miR-140-3p	1.36	0.0232
15	miR-144	1.35	0.0166

Among the 25 aberrantly expressed miRNAs, only eight miRNAs showed significant changes. miR-4333 expression was found to overlap with that of the well-conserved SNORA53 based on information retrieved from miRBase 20.

Table 2 ischemic reperfusion injury-associated miRNA expression in hypothermic circulatory arrest and sham operation groups

miRNA	miR-10a-3p	miR-10a-5p	miR-21	miR-193a-3p	miR-210	miR-205
FC	-1.23	-1.16	-1.11	-1.11	-1.41	-1.17
P value	0.3752	0.5034	0.6219	0.7919	0.0952	0.6146

Six previously reported ischemic reperfusion injury-associated miRNAs showed nonsignificant changes.