Correlation of human epidermal growth factor receptor protein expression and colorectal cancer

Table 1 Relationship between the expression of human epidermal growth factor receptor protein and the clinicopathological features of colorectal cancer

Clinicopathological parameters		Number of cases	HER-2 positive rate, n (%)	χ2value	P value
Gender	Male	97	17 (17.53)	0.405	0.525
	Female	65	14 (21.54)
Age	≥ 60	74	15 (20.27)	0.113	0.736
	< 60	88	16 (18.19)
Tumor location	Colon	76	17 (22.37)	0.967	0.326
	Rectum	86	14 (16.28)
Tumor size/cm	≥ 5	99	20 (20.20)	0.187	0.665
	< 5	63	11 (17.46)
Dukes staging
	A + B	84	12 (14.29)	6.861	0.009
	C + D	68	19 (27.94)
Degree of differentiation	Well-differentiated	30	6 (20.00)	4.631	0.099
	Moderately differentiated	54	15 (27.78)
	Poorly differentiated	78	10 (12.82)
Lymph node metastasis	With	86	22 (25.58)	4.922	0.027
	Without	76	9 (11.84)
Depth of invasion	Serosa	101	14 (13.86)	4.822	0.028
	Muscular layer	61	17 (27.87)

HER-2: Human epidermal growth factor receptor.