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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Jul 28, 2015; 21(28): 8687-8696
Published online Jul 28, 2015. doi: 10.3748/wjg.v21.i28.8687
Published online Jul 28, 2015. doi: 10.3748/wjg.v21.i28.8687
Correlation of human epidermal growth factor receptor protein expression and colorectal cancer
Wen-Juan Yang, Zhi-Gang Tan, Yan Song, Yi-Tong Guo, Department of Emergency, Jinan Central Hospital affiliated Shandong University, Jinan 250013, Shandong Province, China
Xing-Jie Shen, Xiao-Xia Ma, Department of Gastroenterology, Jinan Central Hospital affiliated Shandong University, Jinan 250013, Shandong Province, China
Mei Yuan, Department of Statistics, the First People’s Hospital of Jining, Jining 272002, Shandong Province, China
Author contributions: Yang W and Tan ZG designed the research; Song Y and Guo YT performed the research; Shen XJ and Ma XX analyzed the data; Yuan M wrote the paper.
Conflict-of-interest statement: The authors have declared that no competing interests exist.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Mei Yuan, MD, Department of Statistics, the First People’s Hospital of Jining, No. 6 Jiankang Road, Jining 272002, Shandong Province, China. songyansy125@126.com
Telephone: +86-531-86968509 Fax: +86-531-86968509
Received: December 19, 2014
Peer-review started: December 21, 2014
First decision: January 22, 2015
Revised: March 23, 2015
Accepted: April 16, 2015
Article in press: April 17, 2015
Published online: July 28, 2015
Peer-review started: December 21, 2014
First decision: January 22, 2015
Revised: March 23, 2015
Accepted: April 16, 2015
Article in press: April 17, 2015
Published online: July 28, 2015
Core Tip
Core tip: The first meta-analysis to evaluate the role of human epidermal growth factor receptor (HER-2) expression in colorectal cancer (CRC); HER-2 expression level is associated with the clinic-pathological features of CRC; HER-2 expression level is associated with the prognostic factors of CRC; HER-2 expression level is a biomarker for diagnosis of CRC; HER-2 expression level is a biomarker for determining the prognosis of CRC.