Copyright ©The Author(s) 2015.
World J Gastroenterol. Jul 7, 2015; 21(25): 7709-7717
Published online Jul 7, 2015. doi: 10.3748/wjg.v21.i25.7709
Table 1 Differences in the prevalence of endoscopic ulcers and erosions in low-dose aspirin users between Western countries and Japan
Ref.CountriesStudy designSample sizeDefinition of ulcersPrevalence of ulcersPrevalence of ulcers and/or erosions
Kordecki et al[11], 1997PolandProspective96Greater than 5 mm-68.0%
Pilotto et al[12], 2004ItalyProspective24525.7%-
Yeomans et al[13], 2005Australia, United Kingdom Canada, Spain,Prospective187Greater than 3 mm10.7%-
Niv et al[14], 2005IsraelProspective46Greater than 3 mm39.1%47.8%
Subtotal478 ulcers, 142 ulcers and/or erosions21.1%61.2%
Shiotani et al[15], 2009JapanProspective305Greater than 5 mm12.4%-
Nema et al[16], 2009JapanProspective236Greater than 5 mm11.0%48.4%
Kawai et al[17], 2010JapanProspective101Greater than 3 mm15.8%-
Tamura et al[18], 2011JapanProspective150Greater than 3 mm4.0%37.3%
Fujisawa et al[19], 2011JapanRetrospective1213Greater than 5 mm5.9%57.3%
Kawamura et al[20], 2013JapanRetrospective226Greater than 5 mm6.2%-
Uemura et al[21], 2014JapanProspective1454Greater than 5 mm6.5%29.2%
Subtotal3685 for ulcers, 3053 for ulcers and/or erosions7.2%36.1%
Table 2 Diverse effects of Helicobacter pylori infection on low-dose aspirin-induced gastroduodenal injury between Western countries and Japan n (%)
Ref.CountriesSubjectsStudy designOutcomesPrevalence of outcomes(H. pylori-positive vs -negative)
Kordecki et al[11], 1997Poland96 chronic LDA usersObservationalEndoscopic ulcers and erosions49 (75) vs 11 (35)
Feldman et al[22], 2001United States61 healthy volunteersInterventional study (LDA vs placebo)Endoscopic ulcers and erosions11 (50) vs 4 (16)
Lanas et al[23], 2002Spain245 chronic LDA usersCase-controlUpper gastrointestinal bleeding88 (46) vs 10 (18)
Pilotto et al[12], 2004Italy245 chronic LDA usersObservationalEndoscopic ulcers41 (37) vs 21 (16)
Hart et al[31], 2010Australia, United Kingdom Canada, Spain,206 chronic LDA usersObservationalEndoscopic erosions27 (40) vs 78 (64)
Shiotani et al[15], 2009Japan305 chronic LDA usersObservationalEndoscopic ulcers22 (13) vs 16 (12)
Tamura et al[18], 2011Japan150 asymptomatic chronic LDA usersObservationalEndoscopic ulcers3 (4.4) vs 3 (3.7)
Watanabe et al[24], 2011Japan75 chronic LDA usersObservationalEndoscopic ulcers7 (20) vs 8 (19)
Uemura et al[21], 2014Japan1454 chronic LDA usersObservationalEndoscopic ulcers59 (8.4) vs 35 (4.6)
Endoscopic erosions132 (19) vs 293 (39)
Iijima et al[25], 2015Japan100 chronic LDA usersObservationalEndoscopic ulcers10 (17) vs 5 (13)