Published online Jul 7, 2015. doi: 10.3748/wjg.v21.i25.7709
Peer-review started: April 8, 2015
First decision: April 23, 2015
Revised: May 14, 2015
Accepted: June 10, 2015
Article in press: June 10, 2015
Published online: July 7, 2015
Core tip: There have been conflicting results about the potential interaction between these low-dose aspirin (LDA) use and Helicobacter pylori (H. pylori) infection on the gastroduodenal ulcers and the geographic areas involved. H. pylori infection could have a synergistic or antagonistic interaction with LDA use in adverse gastroduodenal events depending on gastric acid secretion. Large geographic differences in the net effect of H. pylori infection on gastric acid secretion could be at least partly responsible for the geographically distinct interaction between LDA use and H. pylori infection on adverse gastroduodenal lesions.