Colorectal cancers in ulcerative colitis from a low-prevalence area for colon cancer

Table 1 Comparison of ulcerative colitis patients with and without colorectal cancer

	No malignancy	CRC	P value
Number of patients (males)	418 (242)	12 (5)	0.3751
Age (mean ± SD, yr)	44.5 ± 14.6	49.6 ± 10.1	0.232
Median duration of disease (interquartile range)	6 (7)	18 (8)	0.000013
History of smoking	31	0	1.0
Family history of IBD	24	2	0.15
Pancolitis	159	9	0.01
Left-sided colitis	129	2	1.0
No. of patients on azathioprine	108	2	0.7381
Poor compliance with therapy	144	6	0.23
Poor disease control	50	5	0.0071

¹Fisher’s exact test;

²Unpaired t test;

³Mann Whitney test. CRC: Colorectal cancer; IBD: Inflammatory bowel disease.

Table 2 Characteristics of colorectal cancer in ulcerative colitis

No.	Age (yr)	Sex	Extent of disease	Duration1,yr	Location of CRC
1	59	M	Ext colitis	24	Recto-sigmoid
2	47	F	Left-sided colitis	10	Left colon
3	51	M	Ext colitis	6	Ascending, transverse, descending colon (multifocal)
4	42	M	Ext colitis	7	Rectum
5	64	F	Ext colitis	13	Ascending colon
6	41	F	Ext colitis	17	Descending colon
7	40	F	Left-sided colitis	6	Rectum
8	46	F	Ext colitis	20	Rectum
9	67	F	Left sided	27	Rectum
10	49	M	Ext colitis	22	Rectum
11	56	M	Ext colitis	17	Rectum
12	51	F	Ext colitis	13	Ascending colon

¹Duration from onset of ulcerative colitis to detection of CRC. Ext: Extensive colitis; CRC: Colorectal cancer.