Prospective Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Mar 28, 2015; 21(12): 3644-3649
Published online Mar 28, 2015. doi: 10.3748/wjg.v21.i12.3644
Colorectal cancers in ulcerative colitis from a low-prevalence area for colon cancer
Devendra Desai, Sudeep Shah, Abhijit Deshmukh, Philip Abraham, Anand Joshi, Tarun Gupta, Ramesh Deshpande, Varun Khandagale, Siji George
Devendra Desai, Abhijit Deshmukh, Philip Abraham, Anand Joshi, Tarun Gupta, Varun Khandagale, Siji George, Division of Gastroenterology, P.D Hinduja Hospital, Mumbai 400016, India
Sudeep Shah, Division of Gastrointestinal surgery, Department of Surgery, P.D Hinduja Hospital, Mumbai 400016, India
Ramesh Deshpande, Division of Pathology, Department of Pathology, P.D Hinduja Hospital, Mumbai 400016, India
Author contributions: Desai D contributed to concept of the database on inflammatory bowel disease and this study, data collection and analysis, drafting and revision of the article; Deshmukh A collected and analyzed the data; Abraham P contributed to conceptualization of this study, drafting and revision of the article; Joshi A, Gupta T and Khandagale V contributed to data collection, drafting and revision of the article; Shah S contributed to data collection, drafting and revision of the article, and surgical input; Deshpande R review the pathology slides, collected the data and revised the article; and George S collected the data and drafted the article.
Ethics approval: The study was reviewed and approved by the National Health and Education Society (P D Hinduja Hospital) Institutional Review Board.
Conflict-of-interest: The study received no financial support from any source. None of the authors has any conflict of interest to declare.
Data sharing: No additional data is available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Devendra Desai, MD, Division of Gastroenterology, P D Hinduja Hospital, DNB (Gastroenterology) Room No 1106, OPD Block, Veer Savarkar Marg, Mahim, Mumbai 400016, India. devendracdesai@gmail.com
Telephone: +91-22-24447106
Received: August 31, 2014
Peer-review started: September 1, 2014
First decision: September 27, 2014
Revised: October 11, 2014
Accepted: January 8, 2015
Article in press: January 8, 2015
Published online: March 28, 2015

Abstract

AIM: To determine the incidence and risk factors for colorectal cancer (CRC) in patients with ulcerative colitis from a low prevalence region for CRC.

METHODS: Our prospective database yielded a cohort of 430 patients [age: 44 ± 14.6 years; 248 men (57.7%)] with ulcerative colitis (median disease duration 6, range: 1-39 years) for analysis. Of these, 131 (30.5%) had left-sided colitis and 159 (37%) extensive colitis. Patients with histologically confirmed CRC within the segment with colitis were compared with those without CRC, to determine the risk factors for the development of CRC.

RESULTS: Twelve patients (2.8%) developed CRC. The overall incidence density was 3.56/1000 patient-years of disease - 3/1000 in the first 10 years, 3.3/1000 at 10 to 20 years, and 7/1000 at > 20 years. Three of our 12 patients developed CRC within 8 years of disease onset. On univariate analysis, extensive colitis, longer duration of disease, and poor control of disease were associated with development of CRC. On multivariate analysis, duration of disease and extent of colitis remained significant.

CONCLUSION: CRC occurred in 2.8% of patients with ulcerative colitis in our population - an incidence density similar to that in Western countries in spite of a low overall prevalence of colon cancer in our population. The risk increased with extent and duration of disease.

Key Words: Colon cancer, Dysplasia, Epidemiology, Inflammatory bowel disease, Malignancy

Core tip: From an area with low prevalence of colon cancer, the risk of colorectal cancer (CRC) in patients with ulcerative colitis was as high as in those with high risk of CRC. Some patients developed CRC before the recommended commencement of colonoscopic surveillance for CRC.



INTRODUCTION

The risk of development of colorectal cancer (CRC) in patients with ulcerative colitis varies in literature. A meta-analysis by Eaden et al[1] in 2001 concluded that the cumulative probability of CRC was 2% by 10 years, 8% by 20 years, and 18% by 30 years. The meta-analysis by Lutgens et al[2] shortlisted eight studies from 1988 to 2009 and reported that the risk of CRC is increased in inflammatory bowel disease but is not as high as reported in earlier studies; the pooled standardized incidence rate (SIR) was 1.7 (95%CI: 1.2-2.2).

These studies come from regions where the prevalence of CRC itself is high. India has an incidence of CRC that is approximately a tenth of that in the Western world[3]. It would be interesting to see whether the intrinsically lower risk in the population would translate to a lower overall risk in patients with ulcerative colitis. Previous studies from India do indeed point to a lower risk[4,5]; however, the duration of ulcerative colitis in the patient population evaluated has been low, with only a small percent exceeding 10 year follow up. The recent Asia-Pacific consensus statement on ulcerative colitis highlighted the paucity of data on CRC in the Asian population[6].

In an attempt to diagnose CRC early, various societies have proposed surveillance guidelines[6-8]. Survival benefit from colonoscopic surveillance programmes in ulcerative colitis has not been conclusively established, but there seem to be fewer deaths in patients undergoing surveillance[7-9]. Surveillance guidelines in an otherwise low-risk population should depend on the risk increase of CRC with ulcerative colitis.

We therefore analysed the incidence of CRC in our cohort of patients with ulcerative colitis, in order to identify risk factors and also to determine whether standard recommendations for time-to-surveillance are reasonable for low-risk populations.

MATERIALS AND METHODS

This is an analysis of a prospectively maintained database of a cohort of patients with ulcerative colitis presenting to the Division of Gastroenterology since 2005. The data include demography, history, examination findings, laboratory investigations, colonoscopy (patients with disease proximal to splenic flexure were considered to have extensive colitis) and histology findings, imaging findings, diagnosis, therapy (medical and surgical), duration of disease and therapy, compliance with therapy (taking more than 85% of the prescribed dose of medications was considered “compliant with treatment”), response to treatment, course, complications of disease, and extra-intestinal manifestations.

Currently, colonoscopic surveillance is advised routinely to our patients with more than 8 years’ history of ulcerative colitis, irrespective of extent of disease. Follow up was recorded during their hospital visits, failing which they were contacted by telephone, e-mail or post, for update on their disease status. Patients with less than one-year duration of ulcerative colitis and those with less than one year of follow up were excluded from analysis in this study. Disease control was considered good when bowel frequency was normal, and there was no blood in stool and no systemic symptoms; when they were symptomatic, Truelove and Witt’s criteria[10] were used to assess disease severity; mild and moderate activity was considered as average control and severe activity was considered as poor control.

Data of patients with confirmed diagnosis of CRC on endoscopic biopsy and/or operative specimens were analysed with regard to details of location of malignancy, whether it occurred in the segment with macroscopic colitis, stage of disease, presence of metastatic disease, and outcome. These patients were compared to those without malignancy to identify possible risk factors for development of malignancy.

Statistical analysis

Qualitative data are represented as frequency and percentage. Association between qualitative variables was assessed by χ2 test or Fisher’s exact test. P value less than 0.05 was taken as significant. All analyses were done using SPSS Version 13.0.1, IBM, New York. The study was approved by institutional review board

RESULTS

Of the 461 patients with ulcerative colitis in our database, 31 were excluded from analysis (less than one year of duration of disease). Of the 430 patients analysed [age: 44 ± 14.6 years; 248 males (57.7%)], 38 (8.8%) had proctitis, 95 (22.1%) procto-sigmoiditis, 131 (30.5%) left-sided colitis, and 159 (37%) extensive colitis; disease extent was not recorded in 7 patients but all these had extent beyond the rectum. The duration of ulcerative colitis was 1 to 10 years in 301 (70%) patients, 11 to 20 years in 107 (24.9%), and 21 or more years in 22 (5.1%) patients. The median duration of disease was 6 (range: 1-39 years; interquartile range 7) years.

All except three patients received 5-aminosalicylic acid (5-ASA) formulations; 109 (25.3%) patients also received azathioprine. Two hundred forty-four patients were compliant with medications. Disease control was good in 156 (36.3%), poor in 55 (12.8%), and average in the remaining. Thirty-two (7.4%) patients underwent proctocolectomy for suboptimal disease control.

Development of CRCs

Twelve patients (2.79%) developed CRC and six developed non-colorectal malignancies (one each with acute myeloid leukaemia, carcinoma breast, cholangiocarcinoma, endometrial carcinoma, laryngeal cancer and non-Hodgkin lymphoma). The risk of CRC was higher in patients with pancolitis (9/159; 5.6%) than with the other extents of disease (3/130; 2.3%) (P = 0.0125). One CRC was detected during surveillance at 11 years whereas others were detected during work-up for symptoms. The overall incidence density of CRC was 3.6 per 1000 person-year disease (PYD): 2.3/1000 PYD in the first 10 years, 3.3/1000 PYD in the second decade, and 7/1000 PYD thereafter. Three of 12 patients developed CRC within 8 years of disease onset (one patient had lung metastases). Associated primary sclerosing cholangitis was present in four patients - one developed cholangiocarcinoma and one CRC. No patient reported the occurrence of CRC in a first-degree relative.

Analysis of factors affecting the development of CRC

Table 1 compares patients with and without CRC. For univariate analysis, age, gender, duration of disease, extent of colitis, history of smoking, family history of inflammatory bowel disease, medication compliance, and disease control were included. Pancolitis (P = 0.012), longer duration of disease (P = 0.00001), and poor control of disease (P = 0.007) were associated with development of CRC. On multivariate analysis, longer duration of disease (P = 0.01) and pancolitis (P = 0.027) were significant factors for development of malignancy.

Table 1 Comparison of ulcerative colitis patients with and without colorectal cancer.
No malignancyCRCP value
Number of patients (males)418 (242)12 (5)0.3751
Age (mean ± SD, yr)44.5 ± 14.649.6 ± 10.10.232
Median duration of disease (interquartile range)6 (7)18 (8)0.000013
History of smoking3101.0
Family history of IBD2420.15
Pancolitis15990.01
Left-sided colitis12921.0
No. of patients on azathioprine10820.7381
Poor compliance with therapy14460.23
Poor disease control5050.0071
Details of CRCs

Table 2 shows details of the patients with CRC. Malignancy developed at a median of 18 (range: 6-27 years; IQR 8) years after the onset of ulcerative colitis. Tumours were located in the rectum in six patients, recto-sigmoid junction in one, descending colon in one, ascending colon in two, and left colon in one patient. Two patients had multifocal tumours: one had 3 tumours (one each in the ascending, transverse and descending colon), and the other patient had 2 tumours (one each in the ascending colon and at the hepatic flexure).

Table 2 Characteristics of colorectal cancer in ulcerative colitis.
No.Age (yr)SexExtent of diseaseDuration1,yrLocation of CRC
159MExt colitis24Recto-sigmoid
247FLeft-sided colitis10Left colon
351MExt colitis6Ascending, transverse, descending colon (multifocal)
442MExt colitis7Rectum
564FExt colitis13Ascending colon
641FExt colitis17Descending colon
740FLeft-sided colitis6Rectum
846FExt colitis20Rectum
967FLeft sided27Rectum
1049MExt colitis22Rectum
1156MExt colitis17Rectum
1251FExt colitis13Ascending colon

In three patients, CRC developed with disease duration of less than 8 years. The first patient (aged 51 years) with pancolitis developed CRC after 6 years of disease and had 3 tumours. The second patient (aged 42 years), also with pancolitis, had adenoma in the rectum but refused surgery for 2 years. Two years later (7 years’ disease duration) he agreed to surgery when biopsy showed adenocarcinoma in the adenoma. The third patient (aged 40 years) with left-sided colitis was incidentally detected to have lung metastases when she underwent high-resolution CT scan of the chest (at disease duration of 6 years) as part of a study protocol; she was then found to have rectal adenocarcinoma on colonoscopy.

The pathological stage of CRC was known in 10 patients (one patient underwent surgery at another centre and one patient refused surgery and was subsequently lost to follow up): 3 patients had T1 N0 M0 stage, one patient had T2 NO M0 disease, one had T3 N0 M0, and five had nodal involvement. One patient had lung metastases at presentation.

DISCUSSION

Our study found a prevalence rate of 2.8% for colon cancer in a cohort of 430 patients with ulcerative colitis. This is similar to that reported in previously published studies, predominantly from the Western world, where prevalence rates of CRC in ulcerative colitis varied from 0.7% to 3.3%[11-16].

The trend in Asia is not clear; studies have shown that the likelihood of CRC is low, ranging from 0.8% to 1.8%[4,5,17-21]. Our study, taken together with two others from India[4,5], provides insight into the risk of CRC in ulcerative colitis in India. Kochhar et al[4] reported that the risk of CRC in ulcerative colitis was 1.8%; Venkataraman et al[5] reported a lower rate of CRC (0.94%). Our study reports a higher rate (2.79%). This is possibly a result of having a greater number of patients with duration of ulcerative colitis greater than 20 years. The duration of ulcerative colitis has not been specified in the study by Kochhar et al[4], and the lower mean duration of follow up (6 years) in the study from Vellore[5] with no increase in incidence density between 10 and 20 years also suggests a shorter disease duration. Colectomy rates were similar in the two studies (8.8% in the Vellore study[5] and 7.4% in ours) and could not account for the difference.

Two recent studies from the West have reached different conclusions about the increased risk of colon cancer in ulcerative colitis. Jess et al[22], in a population-based study from Denmark, suggested that the risk of colon cancer in ulcerative colitis is not as high as previously reported and in fact may not be different than that in the general population. To the contrary, Herrinton et al[23], from California showed that the risk of CRC in ulcerative colitis is 60% higher than in age- and gender-matched cohorts of people without inflammatory bowel disease, and the risk remained the same throughout the study period of 14.5 years.

Recent data suggest that the age-adjusted rates of CRC in the general Indian population vary from 2.65 to 3.06/100000 in men and 3.40/100000 in women[3,24,25]. The low prevalence of colon cancer in the general population can be seen by the absence of a single case of colon cancer amongst first-degree relatives of our cohort of patients. The risk of CRC in Indian patients with ulcerative colitis thus appears much higher (900 times) than in the general population. This is a much larger risk factor than that in West, owing to the far lower prevalence of colon cancer in the Indian population. This supports the contention that ulcerative colitis is a risk factor for tumour and therefore requires surveillance. If we look at the reason for relatively high prevalence of CRC in an area with low prevalence for CRC, there are no clear answer but some questions arise: It may be related to prevalence of UC in India. A study from India has shown that the incidence and prevalence of UC (incidence 6.02/100000 and prevalence 44.3/100000) is comparable to the west[26]. The prevalence is higher that the rest of Asia[27]. The studies on migrant Indian in Leicestershire have suggested that Indian may be more susceptible to inflammatory bowel disease (IBD) than the caucasians (RR = 2.45)[28,29]. Secondly more than prevalence, it may be related to disease phenotypes in Indian patients. There is mixed literature on this. A study by Walker et al[30] compared the IBD disease phenotypes between South Asians (India, Paksistan and Bangladesh) and Northern Europeans living in London. The phenotype of ulcerative colitis differed significantly: higher number of of South Asian patients had extensive colitis as compared to Northern Eurpean patients (63% vs 42.5%, P = 0.0001); The colectomy rate was non significantly lower in migrant population; they did not study the cancer development. Another study reported in an abstract form compared UC phenotype in native (living in Nagpur, Central India) Indian, Indians migrated to the United States of America (Indian-American) and Caucasian Americans[31]. Proportion of patients with pancolitis was 34.7% in Indians, 65.9% in Indian Americans and 62.9% in Caucasian Americans. Indian Americans were more likely to have colectomy than Indian in India. So the prevalence and disease phenotypes do not seem to explain the high likelihood of CRC. Another factor like disease control may explain the high liklihood of cancer.

Our study showed that pancolitis and duration of disease are significantly associated with increased likelihood of CRC, in keeping with previous literature. Age, gender, history of smoking, family history of inflammatory bowel disease, duration of 5-ASA therapy, azathioprine therapy and compliance with therapy were not significant associations.

Guidelines by various societies suggest that surveillance for CRC should begin after 8 to 10 years of disease duration[7-9]. However, if these recommendations are followed, CRC may be missed. Three of 12 patients with CRC in our study developed the malignancy at 6, 6 and 7 years; one of them had lung metastases at presentation. In another Indian study, by Kochhar et al[4], 2 of 8 patients with ulcerative colitis developed CRC at 7 and 8 years’ disease duration. In the study by Gilat et al[17], 2 of 26 patients who developed CRC in ulcerative colitis had disease duration less than 10 years (6 and 9 years). In the study by Gong et al[21], cumulative risk of CRC in the first decade was 1.15 %, similar to the 1.6 % in the meta-analysis by Eaden et al[1], Lutgens et al[32] reported that 15% of their patients with ulcerative colitis developed CRC before the recommended surveillance. A recent analysis from Surveillance, Epidemiology and End Result (SEER) data suggested an increased rate of missed CRC in older patients with inflammatory bowel disease[33]. It is not clear if this can be applied to patients in other age groups with ulcerative colitis but it has relevance to surveillance strategy. Thus, although a strong body of literature suggests that few patients develop CRC with ulcerative colitis disease duration less than 10 years, it appears that approximately 10% to 20% of cancers may occur earlier during the course of the disease.

In summary, 12 (2.8%) patients with ulcerative colitis in our study developed CRC during a mean follow up of 7.8 years. The overall incidence density of cancer was 3.6 per 1000 person-year disease, with the incidence increasing with each decade. Extensive disease and duration of disease were significant risk factors for the development of CRC. Two patients had multifocal tumours; four of nine patients had nodal involvement, and one had metastases at presentation. A fourth of our patients developed cancer with disease duration less than 8 years. This study points to a significant increase in the incidence of colon cancer in ulcerative colitis over the population incidence and supports the recommendation for screening patients with ulcerative colitis even in a low-endemicity zone for colon cancer.

ACKNOWLEDGMENTS

The authors wish to acknowledge Ms Sangeeta Chhabria for secretarial help in maintaining the database.

COMMENTS
Background

This study presents the prevalence of colorectal cancer (CRC) ulcerative colitis from an area with low prevalence for colon cancer.

Research frontiers

The epidemiology of CRC in ulcerative colitis is changing with many studies suggesting lower CRC rates. This study suggests that CRC prevalence in ulcerative colitis patients from an area with low prevalence for CRC is equivalent to that in the areas with high prevalence for CRCs. The disease extent, severity and other factors do not explain this fully.

Applications

To study the differences in epidemiology in CRC in patients with ulcerative colitis in different parts of and to look at the innovative ways of colonoscopic surveillance in ulcerative colitis.

Peer-review

In this manuscript, the authors assessed the incidence and risk factors for CRC in patients with ulcerative colitis from a low prevalence region for CRC. They concluded that an incidence density of CRC in population with a low overall prevalence of colon cancer similar to that in Western countries, and the risk increased with extent and duration of disease. Their conclusions are reliable. Similar article however, the context lacks of novelty and can not provide new insights into CRC.

Footnotes

P- Reviewer: Arasaradnam RP, Chen CN, Moldovan R, Uchiyama K, Zhu YL S- Editor: Ma YJ L- Editor: A E- Editor: Wang CH

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