Randomized Controlled Trial
Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Nov 21, 2014; 20(43): 16318-16322
Published online Nov 21, 2014. doi: 10.3748/wjg.v20.i43.16318
Table 1 Baseline characteristics and status of ulcer at 4 wk after endoscopic submucosal dissection
Parameter2 wk(n = 27)4 wk(n = 33)P value
Clinical background
Age (yr)73.3 ± 7.870.8 ± 9.3NS2
Gender (male/female)17/1019/14NS3
Helicobacter pylori infection (+/-/unknown)18/8/125/6/2NS3
Location (upper/middle/lower)3/10/141/14/18NS3
Size of ESD (mm2)777.6 ± 437.81251.2 ± 918.60.0484
Serum albumin (g/dL)4.1 ± 0.44.1 ± 0.4NS2
Comorbidity
Diabetes (+/-)3/246/27NS3
Hyperlipidemia (+/-)7/208/25NS3
Hypertension (+/-)8/1911/22NS3
Status of ulcer at 4 wk after ESD1
Stage of ulcer (active/healing/scar)0/20/60/28/5NS2
Ulcer healing rate (%) (average, 95%CI)96.1 (94.6-97.5)94.8 (92.6-97.1)NS3
Table 2 Clinical characteristics of artificial ulcer after endoscopic submucosal dissection treatment with rapid healing
ParameterHealing area in healing stage
P value
≥ 968.5 mm2 (n = 24)< 968.5 mm2 (n = 24)
Age (yr)72.6 ± 8.968.8 ± 9.0NS1
Sex (male/female)15/915/9NS2
Location of tumors (upper/middle/lower third)1/11/121/8/15NS2
Helicobacter pylori infection (+/-/unknown)17/5/216/8/0NS2
Initial ulcer size (mm2)1689.3 ± 835.7633.5 ± 243.8< 0.0013
Healing rate (%)94.6 ± 4.594.0 ± 6.6NS3
Treatment period (2 wk/4 wk)7/1713/11NS2
Comorbidity
Diabetes (yes/no)4/205/19NS2
Hyperlipidemia (yes/no)3/217/17NS2
Hypertension (yes/no)10/143/210.0492
Table 3 Analysis for status of ulcer and healing area in healing stage after adjusting the size of endoscopic submucosal dissection
2 wk(n = 17)4 wk(n = 23)P value
Size of ESD (mm2)962.2 ± 390.81016.2 ± 397.3NS1
Ulcer healing rate (%) (average, 95%CI)94.5 (92.7-96.3)94.0 (91.1-96.9)NS1
Ulcer healing speed in (mm2/mo)908.8 ± 370.6960.7 ± 377.7NS1