Original Article
Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. Nov 21, 2014; 20(43): 16215-16226
Published online Nov 21, 2014. doi: 10.3748/wjg.v20.i43.16215
Table 1 Baseline characteristics of patients with irritable bowel syndrome
CharacteristicsLFD, n = 42LGG, n = 41ND, n = 40P = 0.23
Male/Female8/3414/2711/290.30
Age (yr, range)37 (18-71)43 (20-74)32 (18-73)0.08
BMI (range)23 (19-38)22 (18-34)23 (17-34)0.50
Smoking0.92
Current5 (12)6 (15)6 (15)
Former8 (19)11 (27)11 (27)
Never24 (57)22 (54)22 (55)
Missing521
Disease duration (yr, range)2.6 (0.7-13)1.8 (0.7-15)2 (0.5-9)0.20
Diagnosis subtypes0.24
IBS-A, mixed14 (33)19 (46)14 (35)
IBS-C, constipation5 (12)7 (17)7 (17)
IBS-D, diarrhoeal19 (45)13 (32)18 (35)
Unknown421
Abdominal surgery7 (17)9 (22)6 (15)0.40
IBS related medication16 (38)15 (37)18 (45)0.40
IBS-SSS327 ± 94279 ± 84319 ± 830.17
IBS-QOL56 ± 2164 ± 1557 ± 220.24
Table 2 Change of the irritable bowel syndrome-severity score system from baseline and after 6-wk
IBS-D
IBS-A
IBS-C
Baseline6-wkP valueBaseline6-wkP valueBaseline6-wkP value
LFD320 ± 110153 ± 136< 0.011359 ± 66241 ± 1110.011289 ± 79200 ± 620.14
LGG297 ± 99199 ± 1020.011251 ± 64187 ± 1220.041321 ± 79270 ± 1450.74
ND320 ± 89257 ± 1180.011312 ± 99322 ± 620.12302 ± 70277 ± 1350.61
Table 3 Factors influencing positive changes in irritable bowel syndrome-severity score system at follow-up
EffectContrastDiff SSSLowerUpperP value
AgeBelow 40 yr vs above38.0246-9.433485.48260.11
BMIkg/m20.1812-5.10635.46870.94
GenderFemales vs males8.4693-45.647362.58590.75
IBS subtypeIBS-A vs IBS-D46.10960.657991.56130.041
IBS subtypeIBS-C vs IBS-D50.3197-7.1618107.800.08
IBS medicationYes vs no-54.8795-98.4657-11.29330.011
Prior surgeryYes vs no-11.6029-62.106538.90070.64
IBS-SSSPer baseline SSS point-0.4082-0.6566-0.15980.0011
SmokingCurrent vs never66.04781.0815131.010.041
SmokingFormer vs never51.65423.868299.44010.031
IBS durationPer year4.7145-3.089712.51880.23
Treatment groupLGG vs ND-31.5190-80.776317.73840.20
Treatment groupLFD vs ND-75.3656-126.81-23.92160.0041
Treatment groupLGG vs LFD43.8466-8.078795.77200.09
Table 4 Factors influencing positive changes in irritable bowel syndrome quality of life at follow-up
EffectContrastDiff QOLLowerUpperP value
AgeBelow 40 yr vs above-6.3823-13.62230.85770.08
BMIPer kg/m2-0.2785-1.11850.56150.51
GenderFemales vs males2.2012-6.381610.78400.61
IBS subtypeIBS-A vs IBS-D-6.4508-13.70270.80120.08
IBS subtypeIBS-C vs IBS-D-4.3839-13.54784.78000.34
IBS medicationYes vs no7.97081.020814.92090.021
Prior surgeryYes vs no6.1371-1.959214.23350.13
IBS-QOLPer baseline QOL point-0.2972-0.4739-0.12050.0011
SmokingCurrent vs never-6.2665-16.70744.17430.23
SmokingFormer vs never-6.9729-14.62970.68390.07
Time from diagnosisPer year-0.1678-1.40721.07160.78
Treatment groupLGG vs ND7.2158-0.584415.01600.06
Treatment groupLFD vs ND3.7883-4.400311.97690.36
Treatment groupLGG vs LFD3.4275-4.884411.73950.41