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Copyright ©14 Baishideng Publishing Group Inc.
World J Gastroenterol. Nov 21, 2014; 20(43): 15992-16013
Published online Nov 21, 2014. doi: 10.3748/wjg.v20.i43.15992
Table 1 Amino acid substitutions within the direct-acting antiviral agents target associated with resistance to different direct-acting antiviral agents agents
Drug targetDAA agentsRAV
NS3/4A protease
TelaprevirV36M/A1, T54A/S1, R155K/T1, A156S/T/V1
BoceprevirV36M/A1, T54A/S1, V55A1, R155K/T1, A156S/T/V1, V158I, V170A, M175L
FaldaprevirR155K1, A156T/V, D168V/E1
SimeprevirV36M, F43S, Q80K1, S122A/R, R155K1, A156T/V, D168V/E1, I170T
ABT-450V36M/A/G, V55I, R155K1, A156T/V, D168A/V1
DanoprevirV36M/A, V55I, R155K1, D168E/T1
VaniprevirR155G1/K/N/S/T, A156V, D168V1/G/A
NS5B polymerase
MericitabineS282T, L159F, L320F
BI 207127P495L1/S/A/T/Q, P496S, V499A
Lomibuvir/VX-222L419S1, R422K1, M423TV
SetrobuvirM414T/L, G554D, D559G
NS5A
DaclatasvirM28V/A/T, Q30R/E/H, L31V/M1, Q54H/N/Y, H58D, Q62R/E, A92K/T, Y93H/N/C1
1Amino acid position number represents the key mutations that are clearly associated with virologic failure. A: Alanine; C: Cysteine; D: Aspartate; E: Glutamate; F: Phenylalanine; G: Glycine; H: Histidine; L: Leucine; I: Isoleucine; K: Lysine; M: Methionine; N: Asparagine; P: Proline; Q: Glutamine; R: Arginine; S: Serine; T: Threonine; V: Valine; Y: Tyrosine; DAA: Direct-acting antiviral agents; RAV: Resistant associated variants.