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World J Gastroenterol. Nov 21, 2014; 20(43): 15992-16013
Published online Nov 21, 2014. doi: 10.3748/wjg.v20.i43.15992
Published online Nov 21, 2014. doi: 10.3748/wjg.v20.i43.15992
Hepatitis C virus molecular evolution: Transmission, disease progression and antiviral therapy
Maria Victoria Preciado, Pamela Valva, Laboratorio de Biología Molecular, División Patología, Hospital de Niños “Ricardo Gutiérrez”, Buenos Aires C1425EFD, Argentina
Alejandro Escobar-Gutierrez, Karina Ruiz-Tovar, Carlos Vazquez-Chacon, Armando Martinez-Guarneros, Juan Carlos Carpio-Pedroza, Instituto de Diagnóstico y Referencia Epidemiológicos, Mexico 01480, Mexico
Paula Rahal, Lilian Yamasaki, Department of Biology, Institute of Bioscience, Language and Exact Science, São Paulo State University, São José do Rio Preto, SP 13560-970, Brazil
Salvador Fonseca-Coronado, Laboratorio de Inmunobiología de Enfermedades Infecciosas, Unidad de Investigación Multidisciplinaria, Facultad de Estudios Superiores Cuautitlán, Universidad Nacional Autónoma de México, Cuautitlán Izcalli, Estado de México 54714, Mexico
Mayra Cruz-Rivera, Departmento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico
Author contributions: Preciado VM and Cruz-Rivera M designed and wrote the manuscript; Valva P, Escobar-Gutierrez A, Rahal P, Ruiz-Tovar K, Yamasaki L, Vazquez-Chacon C, Martinez-Guarneros A, Carpio-Pedroza JC and Fonseca-Coronado S collected and analyzed the data.
Supported by Project Salud 2012-C01-181585, CONACYT and PAPIIT TA200112, Dirección General de Asuntos del Personal Academico, Universidad Nacional Autónoma de México (in part); Argentine National Agency for Scientific and Technology Promotion (PICT 2012 Nº804) and National Research Council (CONICET, PIP 2010 Nº51)
Correspondence to: Mayra Cruz-Rivera, Senior Researcher, Departmento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico. mayracr@yahoo.com
Telephone: +52-55-56232466 Fax: +52-55-56232382
Received: May 7, 2014
Revised: June 22, 2014
Accepted: August 13, 2014
Published online: November 21, 2014
Revised: June 22, 2014
Accepted: August 13, 2014
Published online: November 21, 2014
Core Tip
Core tip: Hepatitis C virus (HCV) infection remains as an important public health problem worldwide. Viral molecular evolution determines, in many ways, the outcome of HCV infection. Here, we present up-to-date information about the role of HCV molecular evolution in virus ransmission, disease progression and antiviral therapy.