Role of hydrogen sulfide in portal hypertension and esophagogastric junction vascular disease

Table 1 Comparison of age, liver enzymes and plasma H₂S levels between portal hypertension patients and healthy controls

	Portal hypertension group (n = 200)	Control group (n = 100)
Age (yr)	43.6 ± 14.4	47.1 ± 12.6
Albumin (g/dL)	33.0 ± 3.7	38.4 ± 4.1
TB (μmol/L)	31 ± 24	14 ± 13
ALT (U/L)	37 ± 29	25 ± 26
PVD (cm)	1.5 ± 0.4a	1.1 ± 0.3
H2S		43.5 ± 6.2
Child–Pugh score
A (H2S) n = 48	42.6 ± 4.7a
B (H2S) n = 125	33.5 ± 7.7bc
C (H2S) n = 27	22.2 ± 7.9cdf

Significantly different compared with the control group,

^aP < 0.05,

^bP < 0.01; Compared with Child-Pugh score A group, both Child-Pugh score B and C groups had significantly lower values,

^cP < 0.05,

^dP < 0.01; Compared with the Child-Pugh score B group, the Child-Pugh score C group had a significantly lower value,

^fP < 0.01. TB: Tris-buffered; ALT: Alanine aminotransferase; PVD: Portal vein diameter.

Table 2 H₂S concentration and cystathionine γ-lyase activity in rabbit liver tissues

		Control	SPH
H2S concentration (nmol/mg wet tissue/min)	8W	413.66 ± 57.38	326.43 ± 33.67a
	12W	435.31 ± 442.46	236.57 ± 26.39a
	16W	420.79 ± 31.52	158.64 ± 41.77a
CSE (mmol/mg per min)	8W	120.64 ± 9.37	114.71 ± 11.34
	12W	178.23 ± 19.32	263.32 ± 28.97a
	16W	118.35 ± 9.82	82.67 ± 7.48a

Statistically significant differences compared with the control group,

^aP < 0.05. SPH: Schistosomiasis portal hypertension; CSE: Cystathionine γ-lyase.