Capsule endoscopy in Crohn’s disease: Are we seeing any better?

Table 1 Studies evaluating diagnostic yield of capsule endoscopy

Ref.	Compared modality	n	Diagnostic yield of VCE	Incremental yield of VCE	P value
Albert et al[5]	MRE	27	93%	15%	NS
	SBEC			60%
Hara et al[6]	CTE	17	71%	18%	NS
	Ileoscopy			6%
	SBFT			47%
Solem et al[7]	CTE	28	83%	1%	NS
	Ileocolonoscopy			9%
	SBFT			18%
Dionisio et al[9]	SBR	428	58%	37%	< 0.0001
	Ileocolonoscopy	236	64%	15%	0.000
	CTE	119	70%	39%	< 0.00001
	PE	102	50%	42%	< 0.00001
	MRE	123	50%	7%	NS
Jensen et al[10]	MRE	93	100%	27%	0.03
	CTE		100%	19%	NS

CE: Capsule endoscopy; MRE: Magnetic resonance enterography; CTE: Computed tomography enterography; SBEC: Small bowel enteroclysis; SBFT: Small bowel follow through; SBR: Small bowel radiography; PE: Push enteroscopy; NS: Non-significant.

Table 2 Capsule endoscopy in inflammatory bowel disease unclassified n (%)

Ref.	n	Results
Mow et al[2]	22	9 (40) suspected CD; 5 (23) confirmed CD
Maunoury et al[19]	30	5 (17), CD
Mehdizadeh et al[20]	21	6 (29), CD
Murrell et al[21]	68	15 (22), SB findings

CD: Crohn’s disease; SB: Small bowel.

Table 3 Capsule endoscopy in postoperative Crohn’s disease

Ref.	Compared modality	n	Results
Bourreille et al[26]	IC	31	IC Sens/Spec: 90%/100%
			CE Sens/Spec: 62%-76%/90%-100%
Pons Beltran et al[27]	IC	24	IC recurrence: 25%
			CE recurrence: 68%

IC: Ileocolonoscopy; CE: Capsule endoscopy; Sens/Spec: Sensitivity/Specificity; SICUS: Small intestine contrast ultrasonography.

Table 4 Influence of capsule endoscopy findings on management of Crohn’s disease

Ref.	n	CE findings	Change in management
Dussault et al[28]	71	1Moderate 45%	54%
		2Severe 17%	75%
Long et al[29]	86 (with CD)	1Moderate 30.3%	51%
		2Severe 47.6%	73%
Min et al[30]	50 (with CD)	86%	75%

¹Moderate endoscopic lesions: erythema and a few aphthous ulcers;

²Severe endoscopic lesions: defined as multiple and/or deep ulcers and/or stenosis with/without retention. CD: Crohn’s disease; CE: Capsule endoscopy.