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Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. May 28, 2014; 20(20): 6226-6235
Published online May 28, 2014. doi: 10.3748/wjg.v20.i20.6226
Table 1 Role of polymorphisms of genes encoding cytokines and some regulatory proteins in chronic hepatitis B virus infection
IL-1β-511CPersistent infection[20-22]
IL-1RN2Protective against HBV infection[18]
IL-6-174 G/CNo effect[26]
IL-8-251AAProtective against HBV-related cirrhosis[28]
IL-10-1082GVirus clearance, lower HBV viral load, protective against HBV infection[30,31]
Persistent HBV infection[35]
-592CAVirus clearance[35]
Persistent HBV infection[36]
IL-10R K47EPersistent, chronic infection[38,99]
IL-18-148CVirus clearance[40]
+8925GVirus clearance[40]
+13925CVirus clearance[40]
-137CProtective against HBV[43,44]
-607AAInhibition of HBV DNA replication[43,44]
IL-28BVirus clearance, prevent HBV progression[46]
No effect[51]
TNF-α-863AVirus clearance, persistent infection[68,71,77]
-238APersistent infection[37,58-62,71]
-308AProgressive disease[55,58,66,77]
Protective against chronic HBV infection[76]
-857CCPersistent infection[37,61,62,68]
Protective against chronic HBV infection[75]
IFN-γ+874AAViral load, persistent infection[54]
TGF-β1-509CDevelopment of cirrhosis[80]
Codon 10TDevelopment of cirrhosis[80,83]
Progression to hepatocellular cancer[81,82]