Published online May 28, 2014. doi: 10.3748/wjg.v20.i20.6226
Revised: December 9, 2013
Accepted: January 2, 2014
Published online: May 28, 2014
Core tip: The specific polymorphisms of genes encoding cytokines, such as interleukin (IL)-1, IL-8, IL-10, IL-18, IL-28B, tumor necrosis factor-α, interferon-γ, tumor growth factor-β1, and regulatory molecules such as vitamin D receptor and chemokine receptor 5 affect the clinical course of chronic hepatitis B virus (HBV) infection. This review aims to summarize the literature on cytokine gene polymorphisms and chronic HBV infection and discuss future prospects regarding the clinical implication of these polymorphisms.