Topic Highlight
Copyright ©2014 Baishideng Publishing Group Inc.
World J Gastroenterol. May 28, 2014; 20(20): 5973-5986
Published online May 28, 2014. doi: 10.3748/wjg.v20.i20.5973
Table 1 Examples of dysregulated miRNAs in hepatitis B virus-infected or hepatitis B virus-related hepatocellular carcinoma patients at various locations as compared to healthy or non-tumorous controls
LocationsRegulation1List of miRNAs
HBV serum/plasmaUpmiR-375[64], miR-92a[64], miR-10a[64], miR-223[64], miR-423[64], miR-23b/a[64], miR-342-3p[64], miR-99a[64,75], miR-122a[64], miR-125b[64,75], miR-150[64], let-7c[64], miR-100[75], miR-122[75], miR-122*[75], miR-192[75], miR-192*[75], miR-193b[75], miR-194[75], miR-215[75], miR-365[75], miR-455-5p[75], miR-455-3p[75], miR-483-3p[75], miR-885-5p[75], miR-1247[75]
HBV-HCC serum/plasmaUpmiR-122[81], miR-192[81], miR-194[81], miR-21[81], miR-23b[81], miR-801[81]
DownmiR-223[81], miR-132[104]
Dysplastic nodulesUpmiR-224[73]
DownmiR-145[73], miR-199b[73]
HCC tumoursUpmiR-224[74], miR-27a[112], miR-501[110]
DownmiR-422b[74], miR-122a[74], miR-132[104], miR-148a[108], let-7a[107], miR-101[102]
Table 2 Examples of miRNAs involved in chronic hepatitis B infection or hepatitis B virus-related hepatocellular carcinoma
miRNATarget geneProcess(es) affected
miR-1HDAC4HBV replication
E2F5Cell proliferation; cell cycle
miR-199a-3p, miR-210HBV genomeHBV replication and antigen production
miR-501HBXIPHBV replication
miR-141PPARAHBV replication
miR-29aPTENCell migration
miR-101DNMT3ADNA methylation and gene silencing
let-7STAT3Cell proliferation
miR-148aHPIPCell proliferation; migration; EMT