Larsson G, Shenoy T, Ramasubramanian R, Balakumaran LK, Småstuen MC, Bjune GA, Moum BA. Routine diagnosis of intestinal tuberculosis and Crohn's disease in Southern India. World J Gastroenterol 2014; 20(17): 5017-5024 [PMID: 24803814 DOI: 10.3748/wjg.v20.i17.5017]
Corresponding Author of This Article
Dr. Geir Larsson, Department of Medicine, Unger-Vetlesen Institute, Lovisenberg Diaconal Hospital, NO-0440 Oslo, Norway. larsson.geir@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Brief Article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. May 7, 2014; 20(17): 5017-5024 Published online May 7, 2014. doi: 10.3748/wjg.v20.i17.5017
Table 1 Inclusion and exclusion criteria for study participants
Criteria
Inclusion criteria
Intestinal tuberculosis (as per modified Paustian’s criteria[31,32]: (a), and one or more of (b) and (c) had to be fulfilled)
(a) Endoscopic apparent intestinal tuberculosis: transverse ulcers, pseudopolyps, involvement of fewer than four intestinal segments, patulous ileo-coecal valve (b) Histological evidence of tubercles/granulomas with caseation necrosis in intestinal biopsies (c) Clinical response to antituberculous chemotherapeutic drug treatment (ATT) trial
Crohn’s disease (as per ECCO guidelines 2010[33] and management consensus of inflammatory bowel disease for the Asia-Pacific region 2006[34])
Exclusion of infectious enterocolitis Endoscopic: ileal disease, rectal sparing, confluent deep linear ulcers, aphthoid ulcers, deep fissures, fistulae, skip lesions (segmental disease), cobble-stoning Histological: focal (discontinuous) chronic (lymphocytes and plasma cells) inflammation and patchy chronic inflammation, focal crypt irregularity (discontinuous crypt distortion) and granulomas (not related to crypt injury) Samples from ileum: irregular villous architecture
Exclusion criteria
Malignancy
HIV positive
Age below 18 yr
Table 2 Symptoms, signs and disease associated factors of intestinal tuberculosis and Crohn’s disease n (%)