Multipotent role of platelets in inflammatory bowel diseases: A clinical approach

Table 1 Platelet abnormalities in inflammatory bowel disease

Number and morphological changes	Loss of discoid shape
	Acquisition of pseudopodia
	Size increase
	Count increase (reactive thrombocytosis)
	Density increase
	Granular content augmentation
	MPV value decrease
	PDW value increase
	PCT value increase
Other abnormalities
Overproduction and excretion of granular content products	P-selectin, β-TG, PF-4, fibrinogen, vWF, fibrinolytic inhibitors, coagulation, angiogenic and mitogenic factors
Increased incorporation of receptors in PLT membrane	CD40, P-selectin, GP53, GP IIb/IIIa, receptors for chemokines, cytokines and complement components
Overproduction of PLT-derived microparticles
PLT-PLT aggregates formation
Increased PLT-leukocytes formation

β-TG: β-thromboglobulin; GP: Glycoprotein; IBD: Inflammatory bowel disease; MPV: Mean platelet volume; PCT: Plateletcrit; PDW: Platelet distribution width; PF-4: Platelet factor-4; PLT: Platelets; vWF: Von Willebrand factor.

Table 2 Mean platelet volume correlations with clinical and laboratory parameters in inflammatory bowel disease patients

Ref.	Disease (n)	HC (n)	MPV correlations
Yüksel et al[41]	UC (61)	27	Reduced MPV in UC compared to HC
			Inverse correlation between MPV and disease activity
			Inverse correlation between MPV and disease extent
Järemo et al[39]	UC (18),	12	Reduced MPV in UC patients compared to HC
	CD (9)		Inverse correlation between MPV and disease activity
Güçlü et al[42]	UC (41)	(-)	Reduced MPV in active compared to non-active disease
Voudoukis et al[46]	UC (91), CD(107)	102	Reduced MPV in IBD patients compared to HC Correlation of MPV with Hb and sTfR
Öztürk et al[45]	UC (103), CD (72)	40	Reduced MPV in IBD compared to HC
			MPV decreases after remission in UC
			MPV increases after remission in CD
Kapsoritakis et al[40]	UC (93), CD (66)	38	Correlation between MPV and disease activity indices
			Correlation between MPV and disease extent
Kayahan et al[44]	UC (37)	20	Correlation between MPV and disease activity indices
			Reduced MPV in UC compared to HC
Liu et al[43]	CD (61)	50	Reduced MPV in CD patients compared to HC
			MPV value did not correlate to disease activity

CD: Crohn’s disease; Hb: Hemoglobin; HC: Healthy controls; IBD: Inflammatory bowel diseases; MPV: Mean platelet volume; sTfR: Soluble transferrin receptor; UC: Ulcerative colitis.