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©2014 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Mar 28, 2014; 20(12): 3180-3190
Published online Mar 28, 2014. doi: 10.3748/wjg.v20.i12.3180
Published online Mar 28, 2014. doi: 10.3748/wjg.v20.i12.3180
Multipotent role of platelets in inflammatory bowel diseases: A clinical approach
Evangelos Voudoukis, Konstantinos Karmiris, Department of Gastroenterology, Venizelion General Hospital, 71110 Heraklion, Greece
Ioannis E Koutroubakis, Department of Gastroenterology, University Hospital Heraklion, 71110 Heraklion, Greece
Author contributions: Voudoukis E and Karmiris K contributed to acquisition, analysis, and interpretation of data, as well as drafting of the manuscript; Koutroubakis IE provided the idea, critical review, and final approval of the manuscript.
Correspondence to: Ioannis E Koutroubakis MD, PhD, Associate Professor, Department of Gastroenterology, University Hospital Heraklion, PO BOX 1352, 71110 Heraklion, Crete, Greece. ikoutroub@med.uoc.gr
Telephone: +30-28-1039225 Fax: +30-281-0542085
Received: September 20, 2013
Revised: December 10, 2013
Accepted: January 19, 2014
Published online: March 28, 2014
Revised: December 10, 2013
Accepted: January 19, 2014
Published online: March 28, 2014
Core Tip
Core tip: Many platelets (PLT) changes have been described in IBD, including morphological alterations (mean PLT volume, PLT distribution width, plateletcrit, and augmented granular content), count increase, microparticles release, over-excretion of granular content, and increased formation of PLT-PLT and PLT-leukocyte aggregates, which are all linked to PLT activation induced by inflammatory agonists. In this review article, we present the multipotent role of PLT in human biological paths and emphasize on how PLT participate in the chronic intestinal inflammation process in IBD.